Are Diet Pills Safe?

Written by Dr. Steve Chaney on . Posted in Drugs and Health, Issues, Obesity

Another Diet Pill Bites the Dust

Author: Dr. Stephen Chaney

New Year DietThe New Year is upon us, and everyone is looking for an easy way to lose weight.

Let’s face it. Losing weight is difficult. You have to give up your favorite foods. You’re often hungry and cranky. You have to change your lifestyle. And did I mention that you might need to put on your running shoes and go for a run or, heaven forbid, actually go to the gym.

It’s so much easier to take one of those diet pills. You know the ones I’m talking about. They promise to give you energyburn the fatsuppress your appetite. All you need to do is take one of those little pills every day and, voila, you’re ready to try on that bikini.

It all sounds great. But are those diet pills really safe? A few weeks ago I shared with you that the experts have warned against the use of fat burning sports supplements. They consider them unsafe. Now it’s time to turn our attention to the fat burning diet pills.

Are Diet Pills Safe?

Lots of diet pills have come and gone over the years. Some have just faded away because they didn’t work. They didn’t live up to their claims. Others have been withdrawn from the market by regulatory agencies because they were dangerous or actually killed people- Ma huang and Fen-Phen come to mind, but there have been many others.

And now it looks like yet another diet pill, one called Dexaprine, may have the same fate.

The ads make it sound like a wonder pill.

  • “With one little change…you could feel energy all day long”
  • “With one little change…you can suppress your insatiable appetite”
  • “You can try another unsuccessful diet without it, but when you’re ready…the ultimate fat burner will be waiting for you with open arms.”

The Dark Side

And yet, like most diet pills, it also has a dark side. Side effects include insomnia, sweating, heart palpitations and high blood pressure. As if that weren’t bad enough, the supplement manufacturer that makes Dexaprine conducts no clinical studies on their products, so they have no idea whether their product is safe or not.

And, it appears that it may not be safe. Dutch authorities banned Dexaprine in August after reports of 11 adverse reactions associated with Dexaprine use in Holland since March of this year, including hospitalizations and severe heart problems. British authorizes followed suit the next day and issued a warning against use of “fat burner” supplements in general. It’s probably just a matter of time before other governments step in and ban Dexaprine as well.

And, it’s not just Dexaprine. New diet pills hit the market almost every day. And, they all have those same “magical” claims.

The Only Safe Drug Is A New Drug

It reminds me of the wise advice that a physician colleague of mine gave to the medical students near the start of their first year. He told them “The only safe drug is a new drug”. He went on to say that he didn’t mean that new drugs were safer than the older drugs. It’s just that we don’t know all of their bad side effects until they’ve been on the market for a few years.

Diets pills are no different. They burst on the market full of promise. But, once they’ve been on the market for a year or two, reports of their bad side effects start to appear. We start to learn just how dangerous they are. And, one by one, they all bite the dust.

The Bottom Line

1)     There is no “Tooth Fairy”. There is no “Easter Bunny”. And, there is no magical pill that will SAFELY melt the pounds away. You simply don’t want to risk the diet pill solution – no matter how easy it sounds. No magical, “quick fix” diet solution is worth risking permanent heart damage – or worse.

2)     If you are fortunate to lose weight safely using one of those diet pills, you won’t have learned anything. You won’t have changed anything. The weight will come right back on.

3)     Permanent weight loss requires a permanent change to your lifestyle. Some of those changes will be difficult at first, but once those lifestyle changes become habits – once they become part of who you are, they will become easy.

You can achieve both the weight and the health you want!

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

 

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Comments (5)

  • Victoria Chase

    |

    Dr. Chaney,
    Thank you so much for your wise words!
    Many of my friends are doing the Plexus Slim which is sweeping the market. It does not have any clinical studies to show safety or efficacy. I am so afraid that not only will these people be weighing more next year but may have significant health problems emerge.

    Reply

    • Dr. Steve Chaney

      |

      Dear Victoria,
      With some many companies it is all about marketing. They are only interested in how much money they can make. The sad truth is that without clinical studies neither the company nor the public know whether the product will be safe and effective for months or years.
      Dr. Chaney

      Reply

  • Carmillia

    |

    What do you know about garcina combogia?

    Reply

    • Dr. Steve Chaney

      |

      Dear Carmilla,

      Read my latest post “7 Easy Ways To Spot Fad Diets”. The FTC has given the public clear guidelines for separating good weight loss programs from fad diets, and Garcinia combogia clearly does not meet their criteria for a good weight loss program. There is no magic pill or food that will melt your pounds away. Sorry to disappoint you, but there is no Easter Bunny either.

      Dr. Chaney

      Reply

  • Barbara Saliski

    |

    I have been very impressed with all of the information that I have read. I have already started my family on diet changes, now just to get them moving is the next challenge. Thank you.

    Reply

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Latest Article

Is Our Microbiome Affected By Exercise?

Posted November 6, 2018 by Dr. Steve Chaney

Microbiome Mysteries

Author: Dr. Stephen Chaney

is our microbiome affected by exerciseIn a recent post,  What is Your Microbiome and Why is it Important,  of “Health Tips From The Professor” I outlined how our microbiome, especially the bacteria that reside in our intestine, influences our health. That influence can be either good or bad depending on which species of bacteria populate our gut. I also discussed how the species of bacteria that populate our gut are influenced by what we eat and, in turn, influence how the foods we eat are metabolized.

I shared that there is an association between obesity and the species of bacteria that inhabit our gut. At present, this is a “chicken and egg” conundrum. We don’t know whether obesity influences the species of bacteria that inhabit our gut, or whether certain species of gut bacteria cause us to become obese.

Previous studies have shown that there is also an association between exercise and the species of bacteria that inhabit our gut. In particular, exercise is associated with an increase in bacteria that metabolize fiber in our diets to short chain fatty acids such as butyrate. That is potentially important because butyrate is a primary food source for intestinal mucosal cells (the cells that line the intestine). Butyrate helps those cells maintain the integrity of the gut barrier (which helps prevent things like leaky gut syndrome). It also has an anti-inflammatory effect on the immune cells that reside in the gut.

However, associations don’t prove cause and effect. We don’t know whether the differences in gut bacteria were caused by differences in diet or leanness in populations who exercised regularly and those who did not. This is what the present study (JM Allen et al, Medicine & Science In Sports & Exercise, 50: 747-757, 2018 ) was designed to clarify.  Is our microbiome affected by exercise?

 

How Was The Study Designed?

is our microbiome affected by exercise studyThis study was performed at the University of Illinois. Thirty-two previously sedentary subjects (average age = 28) were recruited for the study. Twenty of them were women and 12 were men. Prior to starting the study, the participants filled out a 7-day dietary record. They were asked to follow the same diet throughout the 12-week study. In addition, a dietitian designed a 3-day food menu based on their 7-day recall for the participants to follow prior to each fecal collection to determine species of gut bacteria.

The study included a two-week baseline when their baseline gut bacteria population was measured, and participants were tested for fitness. This was followed by a 6-week exercise intervention consisting of three supervised 30 to 60-minute moderate to vigorous exercise sessions per week. The exercise was adapted to the participant’s initial fitness level, and both the intensity and duration of exercise increased over the 6-week exercise intervention. Following the exercise intervention, all participants were instructed to maintain their diet and refrain from exercise for another 6 weeks. This was referred to as the “washout period.”

VO2max (a measure of fitness) was determined at baseline and at the end of the exercise intervention. Stool samples for determination of gut bacteria and concentrations of short-chain fatty acids were taken at baseline, at the end of the exercise intervention, and again after the washout period.

In short, this study divided participants into lean and obese categories and held diet constant. The only variable was the exercise component.

 

Is Our Microbiome Affected By Exercise?

is our microbiome affected by exercise fitnessThe results of the study were as follows:

  • Fitness, as assessed by VO2max, increased for all the participants, and the increase in fitness was comparable for both lean and obese subjects.
  • Exercise induced a change in the population of gut bacteria, and the change was comparable in lean and obese subjects.
  • Exercise increased fecal concentrations of butyrate and other short-chain fatty acids in the lean subjects, but not in obese subjects.
  • The exercise-induced changes in gut bacteria and short-chain fatty acid production were largely reversed once exercise training ceased.

The authors concluded: “These findings suggest that exercise training induces compositional and functional changes in the human gut microbiota that are dependent on obesity status, independent of diet, and contingent on the sustainment of exercise.” [Note: To be clear, the exercise-induced changes in both gut bacteria and short-chain fatty acid production were independent of diet and contingent on the sustainment of exercise. However, only the production of short-chain fatty acids was dependent on obesity status.]

 

What Does This Study Mean For You?

is our microbiome affected by exercise gut bacteriaThere are two important take home lessons from this study.

  • With respect to our gut bacteria, I have consistently told you that microbiome research is an emerging science. This is a small study, so you should regard it as the beginning of our understanding of the effect of exercise on our microbiome rather than conclusive by itself. It is consistent with previous studies showing an association between exercise and a potentially beneficial shift in the population of gut bacteria.

The strength of the study is that it shows that exercise-induced changes in beneficial gut bacteria are probably independent of diet. However, it is the first study to look at the interaction between obesity, exercise and gut bacteria, so I would interpret those results with caution until they have been replicated in subsequent studies.

  • With respect to exercise, this may be yet another reason to add regular physical activity to your healthy lifestyle program. We already know that exercise is important for cardiovascular health. We also know that exercise increases lean muscle mass which increases metabolic rate and helps prevent obesity. There is also excellent evidence that exercise improves mood and helps prevent cognitive decline as we age.

Exercise is also associated with decreased risk of colon cancer and irritable bowel disease. This effect of exercise has not received much attention because the mechanism of this effect is unclear. This study shows that exercise increases the fecal concentrations of butyrate and other short-chain fatty acids. Perhaps, this provides the mechanism for the interaction between exercise and intestinal health.

 

The Bottom Line

A recent study has reported that:

  • Exercise induces a change in the population of gut bacteria, and the change was comparable in lean and obese subjects.
  • Exercise causes an increase in the number of gut bacteria that produce butyrate and other short-chain fatty acids that are beneficial for gut health.
  • These effects are independent of diet, but do not appear to be independent of obesity because they were seen in lean subjects but not in obese subjects.
  • The exercise-induced changes in gut bacteria and short-chain fatty acid production are largely reversed once exercise training ceases.

The authors concluded: “These findings suggest that exercise training induces compositional and functional changes in the human gut microbiota that are dependent on obesity status, independent on diet, and contingent on the sustainment of exercise.”

For more details and my interpretation of the data, read the article above.

 

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

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