Dairy Products and Heart Disease

Written by Dr. Steve Chaney on . Posted in Dairy and Heart Disease

Will Eating Cheese Help You Live Longer?

Author: Dr. Stephen Chaney

 

dairy products and heart diseaseA recent study is generating lots of headlines. Here are some examples:

  • Eating Dairy Foods Can Help Reduce Heart Disease Risk.
  • Fermented Dairy-Products May Protect Against Heart Attack.
  • Full-Fat Dairy May Actually Benefit Heart Health.
  • Eating Cheese Might Help You Live Longer.
  • Eating Cheese and Butter Every Day Linked To Living Longer.

My favorite headlines were the ones about cheese and longevity. For example, one headline read: “New Study Finds People That Eat Cheese Live Longer.” The article opened by saying “Sprinkle on another handful of mozzarella on your pizza, add an extra slice of American cheese on your burger, or grab a bite of sharp cheddar with your crackers. A new study published in The Lancet claims that eating cheese reduces your risk of stroke and cardiovascular disease. Now that’s something we like to hear.”

A lot of people must like to hear good news about cheese. The headlines about cheese making you live longer outnumbered all the other headlines by about 3 to 1.

In summary, the claims ranged from dairy foods in general to milk & fermented dairy foods, full-fat dairy foods, cheese, and cheese & butter. Let’s look at the study behind the claims to see which of these claims about dairy products and heart disease are true and which are wishful thinking.

 

How Was The Study Designed?

dairy products and heart disease relationshipThe study behind the headlines (M. Dehghan et al. The Lancet, 392: 2288-2297, 2018 ) was a very ambitious study called PURE (Prospective Urban Rural Epidemiology study). It was a large multinational study of 136,384 individuals aged 35-70 from 21 countries in five continents.

At the beginning of the study participants filled out a country-specific food frequency questionnaire. The data from this survey were broken down into total dairy foods, milk, yogurt, cheese, and butter. The data were also subdivided into low-fat and full-fat dairy foods.

The participants were followed for an average of 9.1 years. The outcomes measured at the end of the study were overall mortality, cardiovascular mortality, cardiovascular disease, heart attack, stroke and heart failure. The way these outcomes were measured was also country specific because the way these data are collected varies from country to country. [Note: There were some other outcomes measured, but for the sake of simplicity I have not included them in the discussion. Their omission does not change the discussion.]

Finally, in case you were wondering, this research was not funded by money from the dairy industry.

 

Dairy Products and Heart Disease Risk?

dairy products and heart disease milkThe results were interesting:

  • Higher intake of total dairy foods (>2 servings/day compared with no intake) was associated with a lower risk of overall mortality (17% less), cardiovascular mortality (23% less), cardiovascular disease (22% less) and stroke (34% less). No association of dairy consumption with heart attack or heart failure was seen.
  • Higher intake of milk (>1 serving per day compared with <0.5 servings/day) was associated with a lower risk cardiovascular disease (18% less).
  • Higher intake of yogurt (>1 serving/day compared with <0.5 servings/day) was associated with a lower risk of overall mortality (17% less) and cardiovascular disease (10% less).
  • No significant effect of cheese was observed for any of the outcomes measured.
  • Butter intake was low and was not associated with any of the outcomes measured.

The authors concluded: “We observed that higher dairy consumption was associated with lower risks of mortality and cardiovascular disease, particularly stroke. Our study suggests that consumption of dairy products should not be discouraged and perhaps should even be encouraged in low-income and middle-income countries where dairy consumption is less.”

 

Will Eating Cheese Help You Live Longer?

  • dairy products and heart disease cheeseThe claims you have been seeing about consumption of dairy foods in general, milk, and yoghurt reducing heart attack risk are supported by this study and several other recent studies.
  • I hate to disappoint you, but the claims about cheese and butter consumption reducing cardiovascular disease and extending lifespan are clearly wishful thinking. They are not supported by this study.

The discussion of full-fat versus low-fat dairy products is more complicated. You are undoubtedly aware that most current dietary guidelines recommend avoiding full-fat dairy foods in favor of low-fat alternatives. Studies like this have led some to question whether these dietary guidelines should be changed.

Interestingly, the authors of the PURE study did not make any claims about the benefits of full-fat dairy foods in their discussion of the results. These claims have all come from internet blogs and articles. Why were the authors of the study reluctant to make that claim? To answer that question I turned to reviews of the study published in the Science Media Center by experts in that field of study. Here were some of their comments:

  • Because dietary guidelines recommending the consumption of low-fat dairy foods exist primarily in western countries (specifically, the US, Canada & Europe) the distribution of low-fat dairy and full-fat dairy was not evenly divided between counties. Most of the low-fat dairy consumption occurred in western countries. In contrast, most of the full-fat dairy consumption occurred in developing countries. That introduces a couple of confounding variables that are unique to this study. For example:
    • In developing countries, diets are often primarily plant-based and tend to be low in sugar and highly processed foods, while in western countries, diets are often primarily meat-based and are high in sugar and highly processed foods. The addition of full-fat dairy to a plant-based diet may not have the same effect as adding it to a pizza or hamburger.
  • In developing countries, people with higher incomes, a healthier lifestyle, and better access to health care are often the ones who consume more dairy products. In other words, the PURE study can’t tell us whether consumption of full-fat dairy lead to better health outcomes in those countries or whether wealthier and healthier people in those countries had the means to consume more dairy.
  • In many developing countries, a large segment of the population is lactose intolerant. Increased full-fat dairy consumption by these people would be largely yogurt and other fermented dairy foods which have health benefits of their own.

In short, confounding variables unique to this study make it difficult to say with confidence that full-fat dairy foods were just as beneficial as low-fat dairy foods.

In western countries the results of previous studies are mixed. Some suggest that full-fat dairy foods are just as effective as low-fat dairy foods at reducing heart disease risk. Others report that the primary heart-health benefits come from low-fat dairy foods.

 

Dairy Products and Heart Disease:  Diet Context Matters

dairy products and heart disease dietWhy so much confusion? Some recent studies suggest that diet context matters. Simply put, that means the effect of the overall diet is more important than single food groups (dairy). To illustrate this point, let’s look at two other studies.

The first study (M Chen et al, The American Journal of Clinical Nutrition 104: 1209-1217, 2016 ) was published two years ago by investigators at the Harvard Chan School of Public Health. That study included data from 43,000 men in the Health Professionals Follow-Up Study, 87,000 women in the Nurses’ Health Study, and 90,000 women in the Nurses’ Healthy Study II. All these study participants were from the United States. This study put dairy fat consumption into the context of the overall diet. The main findings were:

  • Full-fat dairy foods did not increase heart disease risk compared to a diet that contains high amounts of refined carbohydrates and sugar (the typical American diet).
  • However, when dairy fat was replaced with the same number of calories from:
    • vegetable fat, the risk of heart disease decreased by 10%.
    • polyunsaturated fat, the risk of heart disease decreased by 24%.
    • healthy carbohydrates (fruits, vegetables, and whole grains), the risk of heart disease decreased by 28%.

In other words, the effect of dairy fat on heart disease depends on the overall diet. If you add dairy fat to an already bad, heart-unhealthy diet, it does not further increase heart disease risk. (This finding may explain why several recent studies of western populations have found no difference between full-fat and low-fat dairy consumption.) However, this study also shows that addition of full-fat dairy to a heart-healthy diet is likely to increase heart disease risk.

The lead author of that study was quoted as saying: “These results suggest that dairy fat is not an optimal type of fat in our diets. Although one can enjoy moderate amounts of full-fat dairy such as cheese, a healthy diet pattern tends to be low in saturated fat. These results strongly support existing recommendations to choose mainly unsaturated fats from vegetable oils, nuts, seeds, avocados, and some oily fish for a heart-healthy diet.”

The second major study is the 7th-Day Adventist study, which I have described in detail in my book “Slaying The Food Myths.”  This study showed that a lacto-ovo vegetarian diet was less heart healthy than a vegan diet but is far heart-healthier than the typical American diet.

 

What Does This Study Mean For You?

dairy products and heart disease questionsDairy foods are good for you: Increased consumption of dairy foods, milk, and yogurt are associated with decreased risk of heart disease. As I have said before, we have 5 food groups for a reason. Dairy foods are an essential part of a healthy diet.

  • If you are lactose-intolerant I have good news for you. Yogurt and other fermented dairy foods are probably even better for you than non-fermented dairy foods.
  • If you are avoiding dairy for other reasons, be sure to get your calcium, magnesium, and vitamin D from other sources. There may be other important nutrients in dairy that are heart-healthy, but these are the ones we are sure of.

The jury is still out on full-fat dairy products: It is best to follow current dietary guidelines and consume primarily low-fat dairy products.

If you are a cheese lover, it is probably OK to consume moderate amounts of cheese or other full-fat dairy foods on occasion as part of a heart-healthy, primarily plant-based diet. In short, it is probably better to add a little cheese to a green salad than it is to add it to pizza or a hamburger. It is probably better to pair your cheddar with an apple than with crackers.

Hopefully, this gives you a better understanding of the relationship between dairy products and heart disease.

 

The Bottom Line 

A recent study looked at the consumption of dairy products and heart disease risk, and overall mortality risk in a study with 134,000 participants from 21 countries on five continents. The media response to this study has been overwhelming. Some of the recent headlines are:

  • Eating Dairy Foods Can Help Reduce Heart Disease Risk.
  • Fermented Dairy-Products May Protect Against Heart Attack.
  • Full-Fat Dairy May Actually Benefit Heart Health.
  • Eating Cheese Might Help You Live Longer.
  • Eating Cheese and Butter Every Day Linked To Living Longer.

The first two claims were supported by the study results. The claims about cheese and butter were wishful thinking. They were not supported by the study results. The claim about full-fat dairy was supported by the data, but the authors of the study did not make that claim because of study limitations.

Another recent study of 220,000 participants in the United States provides a better estimate of the effect of full-fat dairy foods on heart health. The main findings of this study were:

  • Full-fat dairy foods did not increase heart disease risk compared to a diet that contains high amounts of refined carbohydrates and sugar (the typical American diet).
  • However, when dairy fat was replaced with the same number of calories from:
    • vegetable fat, the risk of heart disease decreased by 10%.
    • polyunsaturated fat, the risk of heart disease decreased by 24%.
    • healthy carbohydrates (fruits, vegetables, and whole grains), the risk of heart disease decreased by 28%.

In other words, the effect of dairy fat on heart disease depends on the overall diet. If you add full-fat dairy to an already bad heart-unhealthy diet, it does not further increase heart disease risk. However, if you add full-fat dairy to a heart-healthy diet, it is likely to increase heart disease risk.

For more details and a thorough discussion of the full-fat versus low-fat controversy read the article above.

 

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

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Does Magnesium Optimize Vitamin D Levels?

Posted February 12, 2019 by Dr. Steve Chaney

The Case For Holistic Supplementation

Author: Dr. Stephen Chaney

 

Does magnesium optimize vitamin D levels?

magnesium optimize vitamin dOne of the great mysteries about vitamin D is the lack of correlation between vitamin D intake and blood levels of its active metabolite, 25-hydroxyvitamin D. Many people who consume RDA levels of vitamin D from foods and/or supplements end up with low blood levels of 25-hydroxyvitamin D. The reason(s) for this discrepancy between intake of vitamin D and blood levels of its active metabolite are not currently understood.

Another great mystery is why it has been so difficult to demonstrate benefits of vitamin D supplementation. Association studies show a strong correlation between optimal 25-hydroxyvitamin D levels and reduced risk of heart disease, cancer, and other diseases. However, placebo-controlled clinical trials of vitamin D supplementation have often come up empty. Until recently, many of those studies did not measure 25-hydroxyvitamin D levels. Could it be that optimal levels of 25-hydroxyvitamin D were not achieved?

The authors of the current study hypothesized that optimal magnesium status might be required for vitamin D conversion to its active form. You are probably wondering why magnesium would influence vitamin D metabolism. I had the same question.

The authors pointed out that:

  • Magnesium status affects the activities of enzymes involved in both the synthesis and degradation of 25-hydroxyvitamin D.
  • Some clinical studies have suggested that magnesium intake interacts with vitamin D intake in affecting health outcomes.
  • If the author’s hypothesis is correct, it is a concern because magnesium deficiency is prevalent in this country. In their “Fact Sheet For Health Professionals,” the NIH states that “…a majority of Americans of all ages ingest less magnesium from food than their respective EARs [Estimated Average Requirement]; adult men aged 71 years and older and adolescent females are most likely to have low intakes.” Other sources have indicated that magnesium deficiency may approach 70-80% for adults over 70.

If the author’s hypothesis that magnesium is required for vitamin D activation is correct and most Americans are deficient in magnesium, this raises some troubling questions.

  • Most vitamin D supplements do not contain magnesium. If people aren’t getting supplemental magnesium from another source, they may not be optimally utilizing the vitamin D in the supplements.
  • Most clinical studies involving vitamin D do not also include magnesium. If most of the study participants are deficient in magnesium, it might explain why it has been so difficult to show benefits from vitamin D supplementation.

Thus the authors devised a study (Q Dai et al, American Journal of Clinical Nutrition, 108: 1249-1258, 2018 ) to directly test their hypothesis.

 

How Was The Study Designed?

magnesium optimize vitamin d studyThe authors recruited 180 volunteers, aged 40-85, from an ongoing study on the prevention of colon cancer being conducted at Vanderbilt University. The duration of the study was 12 weeks. Blood was drawn at the beginning of the study to measure baseline 25-hydroxyvitamin D levels. Three additional blood draws to determine 25-hydroxyvitamin D levels were performed at weeks 1, 6, and 12.

Because high blood calcium levels increase excretion of magnesium, the authors individualized magnesium intake based on “optimizing” the calcium to magnesium ratio in the diet rather than giving everyone the same amount of magnesium. The dietary calcium to magnesium ratio for most Americans is 2.6 to 1 or higher. Based on their previous work, they considered an “ideal” calcium to magnesium ratio to be 2.3 to 1. The mean daily dose of magnesium supplementation in this study was 205 mg, with a range from 77 to 390 mg to achieve the “ideal” calcium to magnesium ratio. The placebo was an identical gel capsule containing microcrystalline cellulose.

Two 24-hour dietary recalls were conducted at baseline to determine baseline dietary intake of calcium and magnesium. Four additional 24-hour dietary recalls were performed during the 12-week study to assure that calcium intake was unchanged and the calcium to magnesium ratio of 2.3 to 1 was achieved.

In short this was a small study, but it was very well designed to test the author’s hypothesis.

 

Does Magnesium Optimize Vitamin D Levels?

 

does magnesium optimize vitamin d levelsThis was a very complex study, so I am simplifying it for this discussion. For full details, I refer you to the journal article (Q Dai et al, American Journal of Clinical Nutrition, 108: 1249-1258, 2018).

The most significant finding was that magnesium supplementation did affect blood levels of 25-hydroxyvitamin D. However, the effect of magnesium supplementation varied depending on the baseline 25-hydroxyvitamin D level at the beginning of the study.

  • When the baseline 25-hydroxyvitamin D was 20 ng/ml or less (which the NIH considers inadequate), magnesium supplementation had no effect on 25-hydroxyvitamin D levels.
  • When the baseline 25-hydroxyvitamin D was 20-30 ng/ml (which the NIH considers the lower end of the adequate range), magnesium supplementation increased 25-hydroxyvitamin D levels.
  • When the baseline 25-hydroxyvitamin D level approached 50 ng/ml (which the NIH says may be “associated with adverse effects”), magnesium supplementation lowered 25-hydroxyvitamin D levels.

The simplest interpretation of these results is:

  • When vitamin D intake is inadequate, magnesium cannot magically create 25-hydroxyvitamin D from thin air.
  • When vitamin D intake is adequate, magnesium can enhance the conversion of vitamin D to 25-hydroxyvitamin D.
  • When vitamin D intake is too high, magnesium can help protect you by lowering 25-hydroxyvitamin D levels.

The authors concluded: “Our findings suggest that optimal magnesium status may be important for optimizing 25-hydroxyvitamin D status. Further dosing studies are warranted…”

 

What Does This Study Mean For You?

magnesium optimize vitamin d for youThis was a groundbreaking study that has provided novel and interesting results.

  • It provides the first evidence that optimal magnesium status may be required for optimizing the conversion of vitamin D to 25-hydroxyvitamin D.
  • It suggests that optimal magnesium status can help normalize 25-hydroxyvitamin D levels by increasing low levels and decreasing high levels.

However, this was a small study and, like any groundbreaking study, has significant limitations. For a complete discussion of the limitations and strengths of this study I refer you to the editorial (S Lin and Q Liu, American Journal of Clinical Nutrition, 108: 1159-1161, 2018) that accompanied the study.

In summary, this study needs to be replicated by larger clinical studies with a more diverse study population. In order to provide meaningful results, those studies would need to carefully control and monitor calcium, magnesium, and vitamin D intake. There is also a need for mechanistic studies to better understand how magnesium can both increase low 25-hydroxyvitamin D levels and decrease high 25-hydroxyvitamin D levels.

However, assuming the conclusions of this study to be true, it has some interesting implications:

  • If you are taking a vitamin D supplement, you should probably make sure that you are also getting the DV (400 mg) of magnesium from diet plus supplementation.
  • If you are taking a calcium supplement, you should check that it also provides a significant amount of magnesium. If not, change supplements or make sure that you get the DV for magnesium elsewhere.
  • I am suggesting that you shoot for the DV (400 mg) of magnesium rather than reading every label and calculating the calcium to magnesium ratio. The “ideal” ratio of 2.3 to 1 is hypothetical at this point. A supplement providing the DV of both calcium and magnesium would have a calcium to magnesium ratio of 2.5, and I would not fault any manufacturer for providing you with the DV of both nutrients.
  • If you are taking high amounts of calcium, I would recommend a supplement that has a calcium to magnesium ratio of 2.5 or less.
  • If you are considering a magnesium supplement to optimize your magnesium status, you should be aware that magnesium can cause gas, bloating, and diarrhea. I would recommend a sustained release magnesium supplement.
  • Finally, whole grains and legumes are among your best dietary sources of magnesium. Forget those diets that tell you to eliminate whole food groups. They are likely to leave you magnesium-deficient.

Even if the conclusions of this study are not confirmed by subsequent studies, we need to remember that magnesium is an essential nutrient with many health benefits and that most Americans do not get enough magnesium in their diet. The recommendations I have made for optimizing magnesium status are common-sense recommendations that apply to all of us.

 

The Case For Holistic Supplementation

 

magnesium optimize vitamin d case for holistic supplementationThis study is one of many examples showing that a holistic approach to supplementation is superior to a “magic bullet” approach where you take individual nutrients to solve individual problems. For example, in the case of magnesium and vitamin D:

  • If you asked most nutrition experts and supplement manufacturers whether it is important to provide magnesium along with vitamin D, their answer would likely be “No”. Even if they are focused on bone health, they would be more likely to recommend calcium along with vitamin D than magnesium along with vitamin D.
  • If your doctor has tested your 25-hydroxyvitamin D levels and recommended a vitamin D supplement, chances are they didn’t also recommend that you optimize your magnesium status.
  • Clinical studies investigating the benefits of vitamin D supplementation never ask whether magnesium intake is optimal.

That’s because most doctors and nutrition experts still think of nutrients as “magic bullets.” I cover holistic supplementation in detail in my book “Slaying The Supplement Myths.”  Other examples that make a case for holistic supplementation that I cover in my book include:

  • A study showing that omega-3 fatty acids and B vitamins may work together to prevent cognitive decline. Unfortunately, most studies looking at the effect of B vitamins on cognitive decline have not considered omega-3 status and vice versa. No wonder those studies have produced inconsistent results.
  • Studies looking at the effect of calcium supplementation on loss of bone density in the elderly have often failed to include vitamin D, magnesium, and other nutrients that are needed for building healthy bone. They have also failed to include exercise, which is essential for building healthy bone. No wonder some of those studies have failed to find an effect of calcium supplementation on bone density.
  • A study reported that selenium and vitamin E by themselves might increase prostate cancer risk. Those were the headlines you might have seen. The same study showed Vitamin E and selenium together did not increase prostate cancer risk. Somehow that part of the study was never mentioned.
  • A study reported that high levels of individual B vitamins increased mortality slightly. Those were the headlines you might have seen. The same study showed that when the same B vitamins were combined in a B complex supplement, mortality decreased. Somehow that observation never made the headlines.
  • A 20-year study reported that a holistic approach to supplementation produced significantly better health outcomes.

In summary, vitamins and minerals interact with each other to produce health benefits in our bodies. Some of those interactions we know about. Others we are still learning about. When we take high doses of individual vitamins and minerals, we create potential problems.

  • We may not get the full benefit of the vitamin or mineral we are taking because some other important nutrient(s) may be missing from our diet.
  • Even worse, high doses of one vitamin or mineral may interfere with the absorption or enhance the excretion of another vitamin or mineral. That can create deficiencies.

The same principles apply to our diet. I mentioned earlier that whole grains and legumes are among the best dietary sources of magnesium. Eliminating those two foods from the diet increases our risk of becoming magnesium deficient. And, that’s just the tip of the iceberg. Any time you eliminate foods or food groups from the diet, you run the risk of creating deficiencies of nutrients, phytonutrients, specific types of fiber, and the healthy gut bacteria that use that fiber as their preferred food source.

The Bottom Line

 

A recent study suggests that optimal magnesium status may be important for optimizing 25-hydroxyvitamin D status. This is one of many examples showing that a holistic approach to supplementation is superior to a “magic bullet” approach where you take individual nutrients to solve individual problems. For example, in the case of magnesium and vitamin D:

  • If you asked most nutrition experts and supplement manufacturers whether it is important to provide magnesium along with vitamin D, their answer would likely be “No.”  Even if they are focused on bone health, they would be more likely to recommend calcium along with vitamin D than magnesium along with vitamin D.
  • If your doctor has tested your 25-hydroxyvitamin D levels and recommended a vitamin D supplement, chances are he or she did not also recommend that you optimize your magnesium status.
  • Clinical studies investigating the benefits of vitamin D supplementation never ask whether magnesium intake is optimal. That may be why so many of those studies have failed to find any benefit of vitamin D supplementation.

I cover holistic supplementation in detail in my book “Slaying The Supplement Myths” and provide several other examples where a holistic approach to supplementation is superior to taking individual supplements.

In summary, vitamins and minerals interact with each other to produce health benefits in our bodies. Some of those interactions we know about. Others we are still learning about. Whenever we take high doses of individual vitamins and minerals, we create potential problems.

  • We may not get the full benefit of the vitamin or mineral we are taking because some other important nutrient(s) may be missing from our diet.
  • Even worse, high doses of one vitamin or mineral may interfere with the absorption or enhance the excretion of another vitamin or mineral. That can create deficiencies.

The same principles apply to what we eat. For example, whole grains and legumes are among the best dietary sources of magnesium. Eliminating those two foods from the diet increases our risk of becoming magnesium deficient. And, that’s just the tip of the iceberg. Any time you eliminate foods or food groups from the diet, you run the risk of creating deficiencies.

For more details about the current study and what it means to you read the article above.

 

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

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