Is The Jellyfish Memory Supplement A Hoax

Written by Dr. Steve Chaney on . Posted in jellyfish memory supplement, Supplements and Health

Are The Claims Too Good To Be True?

Author: Dr. Stephen Chaney

jellyfish memory supplementDid another phony nutritional supplement, the jellyfish memory supplement, just bite the dust? You’ve seen the TV ads reminding us that our memory starts to fade as we age. You’ve heard the claims about a protein derived from a jellyfish improving your memory. You’ve seen graphs summarizing a clinical study proving the product works. It all sounds so compelling. Are those claims too good to be true? According to the FTC and the New York Attorney General’s Consumer Protection Division, the answer is yes.

Is The Jellyfish Memory Supplement A Hoax?

On January 9th 2017, the FTC and the New York Attorney General’s office sued the makers of the “jellyfish memory supplement,” accusing the company of making false and unsubstantiated claims that the product improves memory, provides cognitive benefits, and is “clinically shown” to work.The FTC complaint alleged that the marketers relied on a study that failed to show that their product works better ftcthan a placebo on any measure of cognitive function. In their joint press release the FTC said “The marketers of [the jellyfish supplement] preyed on the fears of older consumers experiencing age-related memory loss. But one critical thing these marketers forgot is that their claims need to be backed up by real scientific evidence.” The New York Attorney General said “The marketing for [the jellyfish supplement] is a clear-cut fraud, from the label on the bottle to the ads airing across the country. It’s particularly unacceptable that this company has targeted vulnerable citizens like seniors in its advertising for a product that costs more than a week’s groceries, but provides none of the health benefits that it claims.”

Why Were The Clinical Study Results So Misleading?

clinical studyI am a strong supporter for innovation in supplement development. However, innovative products should be backed up by published clinical studies showing significant benefit before being marketed to the public. Unfortunately, the clinical study cited for the “jellyfish memory supplement” does not meet this standard.

  • The study has not been published in a peer-reviewed scientific journal. That means the study has not been independently reviewed by anyone not associated with the manufacturer.
  • When you actually analyze the data, it turns out that the improvement in memory was inconsistent from subject to subject, and the overall results were not statistically significant.
  • The graph shown on TV shows a 20% improvement in memory in just 90 days. In fact, that degree of improvement was only experienced by a very small subset of users. Most users experienced either no improvement or an insignificant 5-10% improvement. The graph the company used to market their product was clearly misleading.

Why Was The Scientific Rationale For The Product So Misleading?

misleading studyApoaequorin, the jellyfish protein in question, is a calcium binding protein. The manufacturer claims that it improves calcium balance in the body, which improves brain function. There are numerous fallacies in that model. For example:

  • Apoaequorin is not found in humans. In fact, the manufacturer does not even use the protein found in jellyfish. They use a synthetic version produced through genetic engineering.
  • Calcium balance is very tightly regulated in the human body. There is no evidence that the addition of apoaequorin, or any other calcium binding protein, improves calcium balance or brain function in humans.
  • Proteins do not enter our bloodstream intact. They have to be degraded to individual amino acids before they can be absorbed. That means when you take a pill containing apoaequorin protein, all you get is a release of amino acids into your bloodstream.
  • Finally, even if you were magically able to get apoaequorin protein into your bloodstream, it couldn’t cross the blood-brain barrier. The only reliable means of getting proteins into the brain is by cranial injection, and I don’t think anyone is going to be doing that for mild cognitive impairment.

The emperor has no clothes! Don’t get me wrong. As someone who is moving into my “golden years,” I would love to see this product succeed. I would love for them to produce clinical evidence that their product makes a statistically significant improvement in memory. I would love for the data to be good enough that it could be published in a peer reviewed journal. I would love for the jellyfish memory supplement to be legitimate. However, I suspect the FTC will win this one. I suspect another bogus product is about to bite the dust.

What Does This Mean For You?

This is just one of many examples of supplements that have first rate marketing, but second rate science. As a consumer, you need to be eternally vigilant. Unfortunately, most of you are not scientists, so it is very difficult for you to evaluate the claims. The FDA does it’s best to shut down products that are dangerous to your health. The FTC does it’s best to shut down products that make unfounded claims. I will do my best to warn you about about bogus products. However, none of us can keep up with all the dangerous and bogus products that flood the marketplace. At the end of the day, your best defense is to remember that famous quote “If it sounds too good to be true…” The jellyfish memory supplement sounds too good to be true.

The Bottom Line

  • The FTC and New York Attorney General have sued the manufacturers of the “jellyfish memory supplement” that has been so widely advertised on TV. The FTC alleges that the claims for that product are “false and unsubstantiated.”
  • The clinical study cited by the manufacturer was flawed because:
    • The results had not been published in a peer reviewed scientific journal. That means the study has not been independently reviewed by anyone not associated with the manufacturer.
    • The results were not statistically significant.
  • The scientific rationale for the product was flawed because:
    • The “jellyfish protein” is not found in humans. In fact, the manufacturer does not even use the protein found in jellyfish. They use a synthetic version produced through genetic engineering.
    • Proteins must be degraded to individual amino acids before they can be absorbed into the bloodstream. That means when you take a pill containing “jellyfish protein”, all you get is a release of amino acids into your bloodstream.
  • Even if you were magically able to get the protein into your bloodstream, it couldn’t cross the blood-brain barrier. The only reliable means of getting proteins into the brain is by cranial injection, and I don’t think anyone is going to be doing that for mild cognitive impairment.
  • I will do my best to alert you about bogus supplements. The FDA and FTC will do their best to protect you. However, none of us can keep up with all the dangerous and bogus products that flood the marketplace. At the end of the day, your best defense is to remember that famous quote “If it sounds too good to be true…”

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

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Comments (4)

  • EROCA

    |

    I am passionate about your wonderful skill to define the truth. You are surely living with your music being shared with the world. I am happy to share this.

    Reply

  • Merlena Cushing

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    I very much agree with Eroca…Your ability to share “your music” with the world is a blessing to all of us. Likely few take the time to thank you for your generosity, so I am doing so now and want to assure you that I often pass on your articles. This is a fantastic one. I have been skeptical of those “jellyfish” ads from the beginning.

    Reply

  • Merlena Cushing

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    I saw a Prevagen ad again tonight, so maybe the suits against them were dismissed. Hmmmmm.

    Reply

    • Dr. Steve Chaney

      |

      Dear Merlena,
      They are contesting the suit. These things take time to resolve.
      Dr. Chaney

      Reply

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Latest Article

Is Our Microbiome Affected By Exercise?

Posted November 6, 2018 by Dr. Steve Chaney

Microbiome Mysteries

Author: Dr. Stephen Chaney

is our microbiome affected by exerciseIn a recent post,  What is Your Microbiome and Why is it Important,  of “Health Tips From The Professor” I outlined how our microbiome, especially the bacteria that reside in our intestine, influences our health. That influence can be either good or bad depending on which species of bacteria populate our gut. I also discussed how the species of bacteria that populate our gut are influenced by what we eat and, in turn, influence how the foods we eat are metabolized.

I shared that there is an association between obesity and the species of bacteria that inhabit our gut. At present, this is a “chicken and egg” conundrum. We don’t know whether obesity influences the species of bacteria that inhabit our gut, or whether certain species of gut bacteria cause us to become obese.

Previous studies have shown that there is also an association between exercise and the species of bacteria that inhabit our gut. In particular, exercise is associated with an increase in bacteria that metabolize fiber in our diets to short chain fatty acids such as butyrate. That is potentially important because butyrate is a primary food source for intestinal mucosal cells (the cells that line the intestine). Butyrate helps those cells maintain the integrity of the gut barrier (which helps prevent things like leaky gut syndrome). It also has an anti-inflammatory effect on the immune cells that reside in the gut.

However, associations don’t prove cause and effect. We don’t know whether the differences in gut bacteria were caused by differences in diet or leanness in populations who exercised regularly and those who did not. This is what the present study (JM Allen et al, Medicine & Science In Sports & Exercise, 50: 747-757, 2018 ) was designed to clarify.  Is our microbiome affected by exercise?

 

How Was The Study Designed?

is our microbiome affected by exercise studyThis study was performed at the University of Illinois. Thirty-two previously sedentary subjects (average age = 28) were recruited for the study. Twenty of them were women and 12 were men. Prior to starting the study, the participants filled out a 7-day dietary record. They were asked to follow the same diet throughout the 12-week study. In addition, a dietitian designed a 3-day food menu based on their 7-day recall for the participants to follow prior to each fecal collection to determine species of gut bacteria.

The study included a two-week baseline when their baseline gut bacteria population was measured, and participants were tested for fitness. This was followed by a 6-week exercise intervention consisting of three supervised 30 to 60-minute moderate to vigorous exercise sessions per week. The exercise was adapted to the participant’s initial fitness level, and both the intensity and duration of exercise increased over the 6-week exercise intervention. Following the exercise intervention, all participants were instructed to maintain their diet and refrain from exercise for another 6 weeks. This was referred to as the “washout period.”

VO2max (a measure of fitness) was determined at baseline and at the end of the exercise intervention. Stool samples for determination of gut bacteria and concentrations of short-chain fatty acids were taken at baseline, at the end of the exercise intervention, and again after the washout period.

In short, this study divided participants into lean and obese categories and held diet constant. The only variable was the exercise component.

 

Is Our Microbiome Affected By Exercise?

is our microbiome affected by exercise fitnessThe results of the study were as follows:

  • Fitness, as assessed by VO2max, increased for all the participants, and the increase in fitness was comparable for both lean and obese subjects.
  • Exercise induced a change in the population of gut bacteria, and the change was comparable in lean and obese subjects.
  • Exercise increased fecal concentrations of butyrate and other short-chain fatty acids in the lean subjects, but not in obese subjects.
  • The exercise-induced changes in gut bacteria and short-chain fatty acid production were largely reversed once exercise training ceased.

The authors concluded: “These findings suggest that exercise training induces compositional and functional changes in the human gut microbiota that are dependent on obesity status, independent of diet, and contingent on the sustainment of exercise.” [Note: To be clear, the exercise-induced changes in both gut bacteria and short-chain fatty acid production were independent of diet and contingent on the sustainment of exercise. However, only the production of short-chain fatty acids was dependent on obesity status.]

 

What Does This Study Mean For You?

is our microbiome affected by exercise gut bacteriaThere are two important take home lessons from this study.

  • With respect to our gut bacteria, I have consistently told you that microbiome research is an emerging science. This is a small study, so you should regard it as the beginning of our understanding of the effect of exercise on our microbiome rather than conclusive by itself. It is consistent with previous studies showing an association between exercise and a potentially beneficial shift in the population of gut bacteria.

The strength of the study is that it shows that exercise-induced changes in beneficial gut bacteria are probably independent of diet. However, it is the first study to look at the interaction between obesity, exercise and gut bacteria, so I would interpret those results with caution until they have been replicated in subsequent studies.

  • With respect to exercise, this may be yet another reason to add regular physical activity to your healthy lifestyle program. We already know that exercise is important for cardiovascular health. We also know that exercise increases lean muscle mass which increases metabolic rate and helps prevent obesity. There is also excellent evidence that exercise improves mood and helps prevent cognitive decline as we age.

Exercise is also associated with decreased risk of colon cancer and irritable bowel disease. This effect of exercise has not received much attention because the mechanism of this effect is unclear. This study shows that exercise increases the fecal concentrations of butyrate and other short-chain fatty acids. Perhaps, this provides the mechanism for the interaction between exercise and intestinal health.

 

The Bottom Line

A recent study has reported that:

  • Exercise induces a change in the population of gut bacteria, and the change was comparable in lean and obese subjects.
  • Exercise causes an increase in the number of gut bacteria that produce butyrate and other short-chain fatty acids that are beneficial for gut health.
  • These effects are independent of diet, but do not appear to be independent of obesity because they were seen in lean subjects but not in obese subjects.
  • The exercise-induced changes in gut bacteria and short-chain fatty acid production are largely reversed once exercise training ceases.

The authors concluded: “These findings suggest that exercise training induces compositional and functional changes in the human gut microbiota that are dependent on obesity status, independent on diet, and contingent on the sustainment of exercise.”

For more details and my interpretation of the data, read the article above.

 

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

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