Methylfolate and Methyl B12 – Myths or Lies? Part 1

Written by Dr. Steve Chaney on . Posted in Methyl folate

How Did The Myths Arise?

Author: Dr. Stephen Chaney


methylated b liesHow did methylfolate become the center of a myth? 

How are the lies of the food supplement industry created? Some of them start innocently enough. They are often based on a kernel of truth which is misinterpreted by some well-meaning medical doctors. It’s not their fault. We teach future doctors what I call “metabolism light” in medical school. There simply isn’t room in the medical curriculum to teach all the details and nuances of human metabolism. We also try to teach them the basics of how to interpret the scientific literature. However, it takes years of experience to get really good at picking out the strengths and weaknesses of clinical studies.

The doctors form their hypothesis and test it on a few patients. If it works, they publish a paper. At that point their idea is picked up by the “sensationalist” bloggers. These are the bloggers who like to focus on the sensational. They delight in writing about “new findings” that go against what the medical profession has been telling you for years. The bloggers don’t stop there. They usually expand the claims. They ‘cherry pick” the scientific literature by quoting only studies that support their viewpoint, and ignoring studies that refute it. In short, they put together a very compelling story. Soon the story is picked up by other bloggers who embellish it further. After it appears in enough sites, people start believing it. A myth is born.

Then supplement companies get in the act. They sense there is money to be made. They manufacture supplements to provide nutrients supported by the myths. They embellish the mythology even more and put together a compelling story to market their products. This is where the mythology becomes deception. Companies have the responsibility to design their products based on the best science. They have an obligation to tell the truth about their products. They know, or should know, that all their claims are not true. When they make claims they know cannot be true, they are lying to you.

The saga of the methylated B vitamins is a perfect example of how observations based on a kernel of truth became myths and eventually became downright lies. Let me share that story with you.


The Kernel Of Truth About Methylfolate


methylated b folic acidLet’s start with the “kernel of truth” that launched the whole methylfolate saga. It started with a doctor who was having a very difficult time finding a solution for a patient with some significant health issues. The doctor ordered a genetic test and discovered the patient had a deficiency in the methylene tetrahydrofolate reductase (MTHFR) gene. The doctor remembered the reaction catalyzed by MTHFR, and a light bulb went off. “Eureka”, he said. His patient must be unable to make N5-methyltetrahydrofolate (commonly referred to as methyl folate), and methylfolate is required for some very important methylation reactions in the cell.

He gave his patient methylfolate, and the patient’s symptoms got better. The doctor leapt to the conclusion that other patients with MTHFR deficiency needed methyl folate as well. Many of those patients responded to methylfolate as well. He didn’t bother to check whether they responded equally well to folic acid. He just assumed methylfolate was the magic elixir. He wrote a paper on his clinical observations, and the methylfolate story was launched. It all seemed so logical. However, the story was not nearly as straight forward as the doctor and the people publicizing his findings assumed. Let me walk you through some “Metabolism 101”. Don’t worry. There won’t be a quiz.


Why The Original Assumptions About Methylfolate Were Misleading


MTHFR mutants only have a partial loss of activity.

  • Individuals with 2 copies of a mutation from A to C at position 1298 of the MTHFR gene(A1298C homozygotes) comprise about 5% of the US population. They have 60% enzyme activity and appear to be normal in clinical studies.
  • Individuals with 2 copies of a mutation from C to T at position 677 of the MTHFR gene (C677T homozygotes) have 30% enzyme activity. They comprise about 10% of the US population. C677T homozygotes often have elevated homocysteine levels. The homozygous C677T mutation is associated with depression, anxiety, and mood swings in some people, but not in others (I will come back to the significance of that qualifying statement later).
  • C677T heterozygotes (one mutant gene) have 65% activity and are normal.

We Don’t Need 100% MTHFR Activity

space shuttleOur human body is wonderfully designed. For many of our most essential metabolic reactions we have built in redundancy. We don’t require 100% activity of key enzymes. This helps protect us from bad effects of mutations as they arise.

The best analogy I can think of is the US space program. Most space vehicles had built in redundancy so that if one system failed, the mission could go on. For example, you may remember the Hubble space telescope. It was launched with four gyroscopes to keep the telescope pointed in the right direction. After a few years, one gyroscope gave out. That was not a problem because there were three left. A few years latter the second gyroscope gave out. Again, there was no problem because there were still two gyroscopes left. It was only after the third gyroscope gave out that Hubble became a bit “wonky”, and a space shuttle was sent up to replace the gyroscopes. It is the same with MTHFR. Only when you get down to around 30% activity, does it become a bit wonky”. (That’s about as non-technical as I get.)

Not Everyone With MTHFR Deficiency Experiences Symptoms

This is due to a phenomenon my geneticist friends refer to as penetrance. Simply put, that means that not everyone with the same mutation experiences the same severity of symptoms. That is because the severity of a mutation is influenced by diet, lifestyle, and genetic background. Let me start with genetic background. In terms of MTHFR mutants you can think of genetic background as being mutations in a related methylation pathway. People who have a mutation in both MTHFR and a gene in a related pathway will experience more severe symptoms and are more likely to require methyl folate. Once you understand penetrance, you realize that individuals requiring methyl folate may represent only a small subset of people with MTHFR mutations.

Penetrance is a concept that most proponents of the methylfolate hypothesis completely ignore. The most severe MTHFR mutation (C677T homozygote) increases the probability that individuals will exhibit symptoms, but some individuals with that mutation are completely normal. Now that you understand the concepts of redundancy and penetrance, you can understand why that is.


When Did The Kernel of Truth About Methylfolate Become A Myth?


methylated b mythsUp to this point the hype around methylfolate could be chalked up to an honest misunderstanding. The doctors who published the original papers may not have known that MTHFR mutations only resulted in a partial reduction in enzyme activity. They probably didn’t know the concepts of redundancy (our cells don’t need 100% enzyme activity) or penetrance (the same mutation may cause severe symptoms in some patients and have no effect in others). It seemed logical to assume that everyone with a MTHFR mutation might do better with methyl folate supplementation. That was incorrect, but it was an honest mistake.

However, the message was picked up by the bloggers who specialize in sensational stories, especially stories that contradict what experts have been telling you for years. They picked up the methyl folate story and distorted it beyond recognition. They knew that “natural” is a buzz word, so they told you that methylfolate was natural and folic acid is synthetic (I exposed that lie earlier). They told you that methylfolate was better utilized than folic acid. They told you that methylfolate was more effective than folic acid. They told you folic acid was toxic. It was going to increase your risk of heart disease and cancer. Suddenly, it was no longer about people with MTHFR deficiency. You were being told that everyone should avoid folic acid and use methylfolate instead.

methylated b folicOn the surface, these pronouncements should not have passed the “If it sounds too good to be true…” test, or in this case, the “If it sounds too bad to be true…” test. You were being asked the believe that folic acid, which has been in use for over 80 years and is backed by hundreds of studies showing it is safe and effective, was neither safe nor effective. You were asked to believe that the government was poisoning you by fortifying foods with folic acid.

However, to make their blogs sound more convincing, they listed clinical studies supporting their stories. The problem is they “cherry picked” the studies that supported their story and ignored the rest. Their bias was particularly outrageous when it came to the “story” that folic acid increases cancer risks. They ignored 10 or 20 studies showing no cancer risk and reported one suggesting it might increase risk. I call that deceptive.

Unfortunately, the myths created by the bloggers have been repeated often enough that many people now believe they are true. I will debunk their myths next week, but first let me touch on how their deceptions became downright lies.


When Did The Myths About Methylfolate and Methyl B12 Become Lies?


If you are writing a blog, you are covered by “freedom of speech.” You can say whatever you want. It doesn’t have to be true. However, if you are a supplement manufacturer, you are held to a higher standard. Ignorance is no longer an excuse. You can no longer cherry pick the “facts” you like and ignore the rest. You are ethically obligated to research all the available literature and be guided by the best scientific evidence.

Reputable companies have been guided by the scientific evidence and have not jumped on the methylfolate bandwagon. They know folic acid is both safe and effective in a wide variety of clinical situations. They also know that, while methylfolate may be just as effective as folic acid, its potential is largely unproven at this point. It has not been tested in many clinical situations.

Less reputable companies, however, sensed money to be made by capitalizing on the buzz around methylfolate. They repeated the myths of the bloggers to claim that their products were superior to others on the market. They call it marketing. I call it lying. They have an obligation to fact check their claims, and only make claims that are true.

It gets worse. Since lots of people already believed they needed methylfolate, why not extend the claim to one of the methylated B vitamins, methyl B12? That would boost sales even more. The claims for methyl B12 were even more outrageous than for methylfolate. There wasn’t even a “kernel of truth” like MTHFR deficiency to serve as a foundation. The claim was the methyl B12 was needed because of some sort of ambiguous “methylation deficiency”. The lies had become whoppers.

Next week I will debunk the methylfolate and methyl B12 myths. Stay tuned.


The Bottom Line


This week I have shared the story about how the myths about methylfolate and methyl B12 arose and how they eventually became lies. Next week I will debunk the myths.


These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

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Comments (3)

  • Caroline


    I can remember in my DAOM doctoral studies one presenter was talking about methylation and everyone but me knew nothing, so he asked if our Shaklee was methylated and knowing how our B Complex is made, I said yes because I knew he would discuss it as not because of your article. Love our B Complex and sell lots of it, and I even call it a “cheap drunk” for lighting the spirit, energy and well being. I do enjoy your articles because of your educational teaching/history and that always helps me.


  • Fran


    I am a person who almost died because of MTHFR. Because my ability to detox was so poor, chemical pollution built up to extreme levels. All this happened while I was taking Shaklee B complex for thirty years prior to becoming sick. I contend that I would not have become so deathly ill if the B vitamins I was taking had been the correct methyl form!! I also will say that your “scientific” research is flawed and gives the wrong answer because you tested blood, not what actually gets into the cells. It does not matter what is in the blood, if it cannot get into the cells. That is the case with folic acid. Contact Dr. Ben Lynch. He has been researching this for many years. He has the correct answers. YOU do not.
    Thank you for giving me the opportunity to tell you about this. I’d be happy to speak directly with you regarding my severe experience with MTHFR, and how the methyl forms of folate and B12 saved my life.


    • Dr. Steve Chaney


      Dear Fran,

      I have consistently said that there are a few people who need methylfolate. These are individuals with several other mutations affecting pathways involving methylation reactions in addition to MTHFR. Situations like yours are exceedingly rare because multiple mutations are required. Published clinical studies show that most people with MTHFR deficiency do quite well with folic acid.

      Folic acid gets into cells quite easily and is immediately converted to folates, including methylfolate – even in individuals with MTHFR deficiency. Again, this is based on published clinical studies.

      I have been in touch with Dr. Ben Lynch and have pointed out the errors in his assertions. Many of his “answers” are contradicted by published clinical studies.

      Dr. Chaney


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Recent Videos From Dr. Steve Chaney


Latest Article

Calf Cramps Remedy

Posted February 20, 2018 by Dr. Steve Chaney

Don’t Let A Leg Cramp Stop You Short

Author: Julie Donnelly, LMT – The Pain Relief Expert

Editor: Dr. Steve Chaney


calf cramps remedyGetting a leg cramp while you are running can be the “straw that broke the camel’s back.”  If you don’t treat it properly and quickly when it is happening, you may limp to the finish line, and you can suffer from its effects for days afterward.  I will show you the best calf cramps remedy below.  First, let’s go over spasms and muscle cramps.

A spasm and a cramp are similar because it’s a shortening in the muscle fiber, but that’s where the similarity ends. A spasm is a slow-forming shortening of a group of fibers that tie up into a knot in the muscle. You can feel a spasm with your fingertips, it feels like a bump as you slide along the full length of the muscle. With a spasm, as you press down and slide, it doesn’t hurt until you get to the spasm, and then it can really hurt. But then it stops hurting as you slide off the spasm. A spasm refers pain to the insertion points of the muscle and frequently doesn’t hurt where the spasm has formed (that is, until you press on it).

Why Do Your Muscles Cramp?

calf cramps remedy muscle crampsA cramp (Charlie horse) is when all the fibers of the entire muscle suddenly and violently contract. The muscle will quickly shorten and can go into a huge knot, or it will just totally shorten.

Usually a cramp happens in your calf muscle, although it can happen to any muscle in the body.  Your calf is comprised of two major muscles, the gastrocnemius and soleus. The gastrocnemius, which is shown in this graphic, originates behind your knee and inserts into your Achilles tendon.

Visualize the muscle suddenly shortening, pulling up on your Achilles tendon, and becoming a mass of tight knots through the entire muscle.

Muscles have an “all or nothing” response.  This means that when a muscle fiber contracts, it will shorten 100% of its length.  It never starts to shorten and then make a U-turn and lengthen.  A cramp is seriously painful, and if you try to stretch it out as it’s happening, you can tear the muscle fibers. In fact, that’s the reason it hurts for sometimes days after the cramp.

A Calf Cramps Remedy You Can Administer Yourself

calf cramps remedy squeezeThe best thing to do is to squeeze the two ends of your calf muscle together, which will help the cramp complete as quickly as possible. This will hurt, but for less time than the normal cramping process.  Hold your calf tightly, as shown in this picture, and continue to press the two ends toward each other.

Hold it until you can breathe normally (about 30-45 seconds), and then release. Breathe for a minute or so, and then push the two ends together again.  This second time won’t hurt, you are only doing it to make sure that all the fibers have completed the contraction.

calf cramps remedy hold sittingOnce you have stopped the cramp, don’t stretch…yet. You need to flush out the hydrogen ions (AKA lactic acid) that rapidly built-up in the muscle during the cramp.

There are many ways to self-treat your calf. If you are out on the road you can either sit on a bench or lie on the ground and put the sore calf onto your opposite knee.  Press down and hold the pressure for 30 seconds. Then deeply press along the muscle going from the back of your knee toward your ankle.

calf cramps remedy opposite footYou can also use your opposite heel and press deeply, straight into your calf.

Start at the top of the muscle and move down toward your ankle. Stop whenever you come to a point that is especially painful. The point should be close to the area shown in this picture.

Hold the pressure for 30-60 seconds, or until it doesn’t hurt anymore.  Release, and then repeat 2-3 times.

Complete this self-treatment by squeezing your calf muscle, like you are wringing out a wet towel.  This will force blood into your muscle and get your circulation moving again.

Proof That My Treatments Work

I once taught this technique at an Ironman Triathlon during a 15-minute session I was giving to the triathletes.  Several days later a triathlete emailed me and told me that he had a cramp as he was running, and he did the treatment I’d taught him.  It cost him a few minutes (he wasn’t in the top three, so the time loss wasn’t a huge issue) but he was able to get up and get back to running, totally without pain.

About a mile later he got a cramp in the other leg, but he automatically started to just stretch it like he’d always done before.  He ended up limping all the way to the finish line, and days later it was still hurting.  He wanted to let me know that my cramp treatment really worked great.  This was especially helpful because I’d always wondered what body chemistry did to the outcome of treating a cramp, and here I found out that chemistry wasn’t involved in the treatment of the muscle fibers.

What To Do After The Calf Cramps Remedy

If the cramp happens during a race or athletic event, knowing how to stop it, and these quick massage techniques, will get you back into the game. But it hasn’t totally resolved the issue. Finally, when you have the time to be detailed (after the race, in the evening, etc.), it is important to work out all the spasms and then stretch properly.

When you are treating the muscles afterward, I suggest you consider getting an analgesic cream that goes way deep into the muscle fibers. Use it when you are massaging the muscle, but don’t put it on before you play, run, or before/after a shower because it will go too deep into the muscle and burn like crazy. After you do the treatments, use ice &/or arnica gel (get it at a good health food store) to heal the bruised muscle fibers and help with pain and swelling. Arnica is fantastic, it’s an amazing homeopathic remedy that has been around for ages and really works.

Naturally you will also want to make sure you hydrate properly and that your diet, vitamins and minerals are all in balance.

calf cramps remedy bookCramping is a common problem athletes face, but with a little bit of effort you can prevent muscle injury and get back in the race quickly!

You can find the full treatments for your muscle cramps by going to my book, Treat Yourself to Pain-Free Living . This book has treatments for your entire body, from your head to your feet.  YOU are your own Best Therapist!  Stop pain quickly and easily with self-treatments you can do anytime, anyplace.

Wishing you well,

Julie Donnelly

julie donnelly

About The Author

Julie Donnelly is a Deep Muscle Massage Therapist with 20 years of experience specializing in the treatment of chronic joint pain and sports injuries. She has worked extensively with elite athletes and patients who have been unsuccessful at finding relief through the more conventional therapies.

She has been widely published, both on – and off – line, in magazines, newsletters, and newspapers around the country. She is also often chosen to speak at national conventions, medical schools, and health facilities nationwide.


These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.