Personalized Nutrition To Change Your Life?

Written by Dr. Steve Chaney on . Posted in Diets, Food and Health, Nutritiion, Personalize Nutrition

Author: Dr. Stephen Chaney

 

personalized nutritionCan a personalize nutrition assessment provide you with information to assist your health strategy?  We’ve been told that genetic testing is the wave of the future. We’ve been promised that genetic testing will tell us which diseases we are most likely to develop. Of course, the unspoken assumption is that if we knew which diseases were most likely to kill us, we’d be highly motivated to make the diet and lifestyle changes needed to reduce the risk of that disease.

But what if a personalized nutrition assessment based on a simple online diet survey was just as effective at getting us to make better food choices as all those fancy genetic tests? That is just what a recent study suggests.

How Was The Study Designed?

food4me surveyThe study was based on a simple online diet survey called Food4Me developed by University College Dublin and Crème Software Ltd. The Food4Me diet survey asks people how many times per week or per day they eat basic food groups and develops personalized diet recommendations based on what they are actually eating. It is a very simple, user friendly, survey requiring only 5-10 minutes to complete. Consumer satisfaction with this kind of survey is high. For example:

  • 92% of participants said that “the Food4Me website was easy to use.”
  • 76% of participants were “satisfied with the detail of information they received in their personalized nutrition report.”
  • 80% of participants felt that “the dietary advice in the report was relevant to them.”

In spite of its simplicity and ease of use, the Food4Me survey is also quite robust. Previous studies have shown that the reproducibility and validity of the Food4Me diet survey compares very favorably with much more extensive dietary analyses (For example, R. Fallaize, et al., Journal of Medical Internet Research, 16: e190, 2014).

This study (International Journal of Epidemiology, 2016, 1-11, doi:110.093/ije/dyw186)  measured the effectiveness of the Food4Me personalized nutrition reports at improving health-related behaviors. It was a 6-month randomized control study of 1269 adults from 7 European countries. It compared 4 different interventions on health-related behavior changes. The 4 interventions were:

  • standardized dietary advice
  • personalized nutrition advice based on the Food4Me survey
  • personalized nutrition advice based on the Food4Me survey plus BMI and blood biomarkers
  • personalized nutrition advice based on all that plus genetic testing

Is Personalized Nutrition The Wave Of The Future?

The results of the study were quite striking:

  • Compared to the group who just received standardized diet advice, the groups who received personalized nutrition advice were significantly more successful at improving health related behaviors. In particular, the groups receiving personalized nutrition advice:
    • personalized nutrition healthy foodConsumed less red meat.
    • Consumed less saturated fat
    • Consumed less salt
    • Got more folate from their diet
    • Had an improved “Healthy Eating Index” (a measure of overall diet quality)
  • Adding information on blood biomarkers (cholesterol, carotenoids, omega-3s, and vitamin D) and genotype received did not enhance the effectiveness of the personalized nutrition recommendations at changing health behaviors.

 

What Does This Study Mean For You?

This is a single study, but it does suggest several interesting take-home lessons.

#1: We are much more likely to follow diet advice that is personalized to us than we are to follow standardized diet advice. This should come as no surprise. We’ve had generalized diet advice like the USDA Food Guide Pyramid and, more recently, the USDA My Plate guidelines for decades, and they haven’t moved the needle. Maybe people think of generalized guidelines as applying to other people and personalized guidelines as applying to them.  Personalized nutrition seems to be more effective.

#2: This was personalized diet advice, not weird diet adviceThe participants were not being told to eat as much fat as they wanted. They weren’t being told that avoiding wheat will make them slimmer and smarter. They weren’t being told to eat like a caveman. They were being given USDA-approved diet recommendations. The only difference was that the dietary recommendations were personalized to them. For example, they were only being told to eat more fruits and vegetables if, in fact, fruits and vegetables were not a regular part of their daily diet. 

#3: Blood biomarkers did not provide any additional incentive to increase health related behaviors. I wouldn’t read too much into this observation. With the exception of cholesterol, the blood biomarkers selected for this study merely reinforced the diet analysis. For example, you could ask whether low blood carotenoid levels really provided any additional incentive to change their diet for an individual who was already told their intake of fruits and vegetables was low. If the study had measured disease-related blood biomarkers, it might have found that they provided additional incentive for individuals to make positive diet changes.

#4: Genetic testing did not provide any additional incentive to increase health related behaviors. This probably simply reflects the state of the science. Current genetic tests are only weakly predictive of major diseases like heart disease, diabetes, and cancer so they provide little incentive to make major lifestyle changes. This may change in the future as we improve our understanding of genetic influences on disease risks.

Missed Opportunities

This study clearly showed that a simple online diet survey like the Food4Me personalized diet assessment is very useful for changing health-related dietary behavior. However, this study also missed several opportunities to create an even more valuable tool for improving health-related behaviors. For example, the study collected data on obesity and activity levels, but did not attempt to provide personalized lifestyle recommendations based on that data. In addition, 44% of the participants reported that they had a disease, but no attempt was made to include health goals in the personalized diet and lifestyle recommendations.

 

The Bottom Line

  • A recent study showed that personalized nutrition recommendations based on a simple online survey were much more effective than standardized dietary advice at getting people to improve health-related eating habits.
  • Adding information on blood biomarkers and genetic tests did not enhance the effectiveness of the personalized nutrition recommendations at changing health behaviors.
  • The study did not evaluate the value of adding activity levels and health goals to the assessment. That perhaps represented a missed opportunity to create an even more powerful tool for positively influencing health-related behaviors.

 

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

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Comments (2)

  • Victoria Dresbach

    |

    Very interesting article. There is so vitamins to choose from and who knows what is the best for you. Your article is an eye opener.

    At this time I have lung cancer and on a targeted therapy drug and I have not read what vitamins would be best. I would love to read an article from you on this subject.

    Thank you.

    Reply

    • Dr. Steve Chaney

      |

      Dear Victoria,
      I report on recently published clinical studies rather than offer opinions or health advice that may or may not be correct. Unfortunately, there are very few studies on vitamins use with targeted drug therapy.
      In general, optimal nutrition supports a strong immune system, and a strong immune system is one of your best defenses against cancer. However, in terms of specific drug-nutrient interactions it is best to consult with your doctor or pharmacist.
      Dr. Chaney

      Reply

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Latest Article

A Low Carb Diet and Weight Loss

Posted January 15, 2019 by Dr. Steve Chaney

Do Low-Carb Diets Help Maintain Weight Loss?

Author: Dr. Stephen Chaney

 

low carb dietTraditional diets have been based on counting calories, but are all calories equal? Low-carb enthusiasts have long claimed that diets high in sugar and refined carbs cause obesity. Their hypothesis is based on the fact that high blood sugar levels cause a spike in insulin levels, and insulin promotes fat storage.

The problem is that there has been scant evidence to support that hypothesis. In fact, a recent meta-analysis of 32 published clinical studies (KD Hall and J Guo, Gastroenterology, 152: 1718-1727, 2017 ) concluded that low-fat diets resulted in a higher metabolic rate and greater fat loss than isocaloric low-carbohydrate diets.

However, low-carb enthusiasts persisted. They argued that the studies included in the meta-analysis were too short to adequately measure the metabolic effects of a low-carb diet. Recently, a study has been published in the British Medical Journal (CB Ebbeling et al, BMJ 2018, 363:k4583 ) that appears to vindicate their position.

Are low carb diets best for long term weight loss?

Low-carb enthusiasts claim the study conclusively shows that low-carb diets are best for losing weight and for keeping it off once you have lost it. They are saying that it is time to shift away from counting calories and from promoting low-fat diets and focus on low-carb diets instead if we wish to solve the obesity epidemic. In this article I will focus on three issues:

  • How good was the study?
  • What were its limitations?
  • Are the claims justified?

 

How Was The Study Designed?

low carb diet studyThe investigators started with 234 overweight adults (30% male, 78% white, average age 40, BMI 32) recruited from the campus of Framingham State University in Massachusetts. All participants were put on a diet that restricted calories to 60% of estimated needs for 10 weeks. The diet consisted of 45% of calories from carbohydrate, 30% from fat, and 25% from protein. [So much for the claim that the study showed low-carb diets were more effective for weight loss. The diet used for the weight loss portion of the diet was not low-carb.]

During the initial phase of the study 161 of the participants achieved 10% weight loss. These participants were randomly divided into 3 groups for the weight maintenance phase of the study.

  • The diet composition of the high-carb group was 60% carbohydrate, 20% fat, and 20% protein.
  • The diet composition of the moderate-carb group was 40% carbohydrate, 40% fat, and 20% protein.
  • The diet composition of the low-carb group was 20% carbohydrate, 60% fat, and 20% protein.

Other important characteristics of the study were:

  • The weight maintenance portion of the study lasted 5 months – much longer than any previous study.
  • All meals were designed by dietitians and prepared by a commercial food service. The meals were either served in a cafeteria or packaged to be taken home by the participants.
  • The caloric content of the meals was individually adjusted on a weekly basis so that weight was kept within a ± 4-pound range during the 5-month maintenance phase.
  • Sugar, saturated fat, and sodium were limited and kept relatively constant among the 3 diets.

120 participants made it through the 5-month maintenance phase.

 

Do Low-Carb Diets Help Maintain Weight Loss?

low carb diet maintain weight lossThe results were striking:

  • The low-carb group burned an additional 278 calories/day compared to the high-carb group and 131 calories/day more than the moderate-carbohydrate group.
  • These differences were even higher for those individuals with higher insulin secretion at the beginning of the maintenance phase of the study.
  • These differences lead the authors to hypothesize that low-carb diets might be more effective for weight maintenance than other diets.

 

What Are The Pros And Cons Of This Study?

low carb diet pros and consThis was a very well-done study. In fact, it is the most ambitious and well-controlled study of its kind. However, like any other clinical study, it has its limitations. It also needs to be repeated.

The pros of the study are obvious. It was a long study and the dietary intake of the participants was tightly controlled.

As for cons, here are the three limitations of the study listed by the authors:

#1: Potential Measurement Error: This section of the paper was a highly technical consideration of the method used to measure energy expenditure. Suffice it to say that the method they used to measure calories burned per day may overestimate calories burned in the low-carb group. That, of course, would invalidate the major findings of the study. It is unlikely, but it is why the study needs to be repeated using a different measure of energy expenditure.

#2: Compliance: Although the participants were provided with all their meals, there was no way of being sure they ate them. There was also no way of knowing whether they may have eaten other foods in addition to the food they were provided. Again, this is unlikely, but cannot be eliminated from consideration.

#3: Generalizability: This is simply an acknowledgement that the greatest strength of this study is also its greatest weakness. The authors acknowledged that their study was conducted in such a tightly controlled manner it is difficult to translate their findings to the real world. For example:

  • Sugar and saturated fat were restricted and were at very similar levels in all 3 diets. In the real world, people consuming a high-carb diet are likely to consume more sugar than people in the other diet groups. Similarly, people consuming the low-carb diet are likely to consume more saturated fat than people in the other diet groups.
  • Weight was kept constant in the weight maintenance phase by constantly adjusting caloric intake. Unfortunately, this seldom happens in the real world. Most people gain weight once they go off their diet – and this is just as true with low-carb diets as with other diets.
  • The participants had access to dietitian-designed prepared meals 3 times a day for 5 months. This almost never happens in the real world. The authors said “…these results [their data] must be reconciled with the long-term weight loss trials relying on nutrition education and behavioral counseling that find only a small advantage for low carbohydrate compared with low fat diets according to several recent meta-analyses.” [I would add that in the real world, people do not even have access to nutritional education and behavioral modification.]

 

low carb diet and youWhat Does This Study Mean For You?

  • This study shows that under very tightly controlled conditions (dietitian-prepared meals, sugar and saturated fat limited to healthy levels, calories continually adjusted so that weight remains constant) a low-carb diet burns more calories per day than a moderate-carb or high-carb diet. These findings show that it is theoretically possible to increase your metabolic weight and successfully maintain a healthy weight on a low-carb diet. These are the headlines you probably saw. However, a careful reading of the study provides a much more nuanced viewpoint. For example, the fact that the study conditions were so tightly controlled makes it difficult to translate these findings to the real world.
  • In fact, the authors of the study acknowledged that multiple clinical studies show this almost never happens in the real world. These studies show that most people regain the weight they have lost on low-carb diets. More importantly, the rate of weight regain is virtually identical on low-carb and low-fat diets. Consequently, the authors of the current study concluded “…translation [of their results to the real world] requires exploration in future mechanistic oriented research.” Simply put, the authors are saying that more research is needed to provide a mechanistic explanation for this discrepancy before one can make recommendations that are relevant to weight loss and weight maintenance in the real world.
  • The authors also discussed the results of their study in light of a recent, well-designed 12-month study (CD Gardener et al, JAMA, 319: 667-669, 2018 ) that showed no difference in weight change between a healthy low-fat versus a healthy low-carbohydrate diet. That study also reported that the results were unaffected by insulin secretion at baseline. The authors of the current study noted that “…[in the previous study] participants were instructed to minimize or eliminate refined grains and added sugars and maximize intake of vegetables. Probably for this reason, the reported glycemic load [effect of the diet on blood sugar levels] of the low-fat diet was very low…and similar to [the low-carb diet].” In short, the authors of the current study were acknowledging that diets which focus on healthy, plant-based carbohydrates and eliminate sugar, refined grains, and processed foods may be as effective as low-carb diets for helping maintain a healthy weight.
  • This would also be consistent with previous studies showing that primarily plant-based, low-carb diets are more effective at maintaining a healthy weight and better health outcomes long-term than the typical American version of the low-fat diet, which is high in sugar and refined grains. In contrast, meat-based, low-carb diets are no more effective than the American version of the low-fat diet at preventing weight gain and poor health outcomes. I have covered these studies in detail in my book “Slaying The Food Myths.”

Consequently, the lead author of the most recent study has said: “The findings [of this study] do not impugn whole fruits, beans and other unprocessed carbohydrates. Rather, the study suggests that reducing foods with added sugar, flour, and other refined carbohydrates could help people maintain weight loss….” This is something we all can agree on, but strangely this is not reflected in the headlines you may have seen in the media.

The Bottom Line

 

  • A recent study compared the calories burned per day on a low-carb, moderate-carb, and high-carb diet. The study concluded that the low-carb diet burned significantly more calories per day than the other two diets and might be suitable for long-term weight control. If confirmed by subsequent studies, this would be the first real evidence that low-carb diets are superior for maintaining a healthy weight.
  • However, the study has some major limitations. For example, it used a methodology that may overestimate the benefits of a low-carb diet, and it was performed under tightly controlled conditions that can never be duplicated in the real world. As acknowledged by the authors, this study is also contradicted by multiple previous studies. Further studies will be required to confirm the results of this study and show how it can be applied in the real world.
  • In addition, the kind of carbohydrate in the diet is every bit as important as the amount of carbohydrate. The authors acknowledge that the differences seen in their study apply mainly to carbohydrates from sugar, refined grains, and processed foods. They advocate diets with low glycemic load (small effects on blood sugar and insulin levels) and acknowledge this can also be achieved by incorporating low-glycemic load, plant-based carbohydrates into your diet. This is something we all can agree on, but strangely this is not reflected in the headlines you may have seen in the media.
  • Finally, clinical studies report averages, but none of us are average. When you examine the data from the current study, it is evident that some participants burned more calories per hour on the high-carb diet than other participants did on the low carb diet. That reinforces the observation that some people lose weight more effectively on low-carb diets while others lose weight more effectively on low-fat diets. If you are someone who does better on a low-carb diet, the best available evidence suggests you will have better long-term health outcomes on a primarily plant-based, low-carb diet such as the low-carb version of the Mediterranean diet.

For more details read the article above.

 

 

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

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