Help Prevent Postpartum Depression with Omega-3s?

Written by Dr. Steve Chaney on . Posted in Omega-3 Deficiency, Postpartum Depression

What Does Science Say About Depression During & After Pregnancy?

Author: Dr. Stephen Chaney

prevent postpartum depressionCan you help prevent postpartum depression by using omega-3s?  Pregnancy and breastfeeding should be a wonderful time in any woman’s life, but sometimes the dark days of depression take hold. Postpartum depression used to be taboo. It was never talked about unless a mother did something terrible enough to make it into the headlines. Nowadays we realize that it is nothing to be ashamed of. In fact, it is fairly common.

The CDC estimates that 11-20% of women will suffer some degree of depression after childbirth. A similar percentage of women will experience prenatal depression (depression during pregnancy). To put these numbers into perspective, 20% of women can expect to suffer depression during their lifetime.

Of course, that doesn’t make prenatal or postnatal (postpartum) depression any easier to understand for any woman who has suffered from it. How could such a joyous time in their lives lead to depression?

The causes of prenatal and postnatal depression are multifactorial. Some, such as genetic predisposition and hormonal imbalances, may be beyond a woman’s control. Others may require medical intervention.

However, many women ask: “Is there something natural, some change in diet and lifestyle, I could undertake that might help with the depression?” This week we will look at a study suggesting that omega-3s might help with prenatal and postnatal depression.

 

Can Omega-3s Help With Prevent Postpartum Depression?

can omega3 prevent postpartum depressionThere are several reasons for suspecting that omega-3s might help with both prenatal and postnatal (postpartum) depression.

  • Many studies have suggested that omega-3 deficiency is implicated in depression.
  • A recent study DHA During Pregnancy  reported that pregnant women in the US are only getting around 1/5 the recommended amount of omega-3s from their diet.
  • During the second and third trimester, the fetus requires tremendous amounts of omega-3s, particularly DHA, to support its developing brain. This could be another instance of the fetus robbing an important nutrient from the mother’s body.

However, clinical studies to date have been inconclusive. Some have shown a clear correlation between omega-3 deficiency and pre/postnatal depressions. Others have not.

The authors of this study (Lin et al, Biological Psychiatry, doi.org/10.1016/j.biopsych.2017.02.1182 ) did a meta-analysis of all studies measuring both omega-3 status and pre/postnatal depression. They included 12 studies with a total of 7739 women in their analysis. Of the women in the study 1094 (16.6%) suffered with prenatal and/or postnatal depression.

Their findings were:

  • Levels of total omega-3s and DHA were significantly lower in the women with prenatal and/or postnatal depression.
  • The ratio of omega-6 to omega-3 fatty acids was higher in the women with prenatal and/or postnatal depression.

 

What Does This Study Mean To You?

healthy livingThis study showed an association between omega-3 deficiency and depression during the prenatal and postnatal periods. It suggests, but does not prove, that omega-3 deficiency predisposes to pre/postnatal depression.  So, taking the recommended amounts of omega-3s may help prevent postpartum depression.

If this were the only reason to suggest adding extra omega-3s to your diet during pregnancy and lactation, it might not be sufficient to spur you to action. However, recent studies suggest that increasing your omega-3 intake during pregnancy and breastfeeding is also important for your child’s brain development. Thus, there are at least two important reasons to make sure your omega-3 intake is optimal during pregnancy and breastfeeding.

It is important to recognize that increasing your omega-3 intake may not be sufficient to cure pre- and postnatal depression by itself. It is probably best as part of a holistic approach. You should also:

  • Make sure you are getting adequate B vitamins (especially folic acid, B6 and B12). Clinical studies have also linked deficiencies of these nutrients with depression.
  • Make sure your protein intake is sufficient and limit sugars and simple carbohydrates. This helps stabilize blood sugar swings that can affect your mood.
  • Keep caffeine to a minimum and avoid alcohol.
  • Employ stress reduction techniques such as yoga, meditation, or conversations with friends.

Of course, there is nothing radical about any of these recommendations. These are the same recommendations every pregnant mother is being given for the health of their baby. For example, the importance of folic acid has been recognized for decades. The importance of omega-3s for your child’s brain development has received increasing recognition in recent years.

Finally, if natural approaches don’t work, consult your physician.

 

The Bottom Line

 

  • A recent meta-analysis has shown an association between omega-3 deficiency and both prenatal and postnatal depression.
  • That is significant in light of a recent study showing that pregnant women in the US are getting only 1/5 the recommended amount of omega-3s from their diet.
  • This study showed an association between omega-3 deficiency and depression during the prenatal and postnatal periods. It suggests, but does not prove, that omega-3 deficiency predisposes to pre/postnatal depression.
  • In addition, recent studies suggest that increasing your omega-3 intake during pregnancy and breastfeeding is also important for your child’s brain development. Thus, there is more than one reason to make sure your omega-3 intake is optimal during pregnancy and breastfeeding.
  • Increasing your omega-3 intake may not cure pre/postnatal depression by itself. It is probably best as part of a holistic approach. You should also:
    • Make sure you are getting adequate B vitamins (especially folic acid, B6 and B12).
    • Make sure your protein intake is sufficient and limit sugars and simple carbohydrates.
    • Keep caffeine to a minimum and avoid alcohol.
    • Employ stress reduction techniques such as yoga, meditation, or conversations with friends.
  • There are many other things that can contribute to depression. If natural approaches don’t work, you should consult your physician.
  • For more details, read the article above.

 

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

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A Low Carb Diet and Weight Loss

Posted January 15, 2019 by Dr. Steve Chaney

Do Low-Carb Diets Help Maintain Weight Loss?

Author: Dr. Stephen Chaney

 

low carb dietTraditional diets have been based on counting calories, but are all calories equal? Low-carb enthusiasts have long claimed that diets high in sugar and refined carbs cause obesity. Their hypothesis is based on the fact that high blood sugar levels cause a spike in insulin levels, and insulin promotes fat storage.

The problem is that there has been scant evidence to support that hypothesis. In fact, a recent meta-analysis of 32 published clinical studies (KD Hall and J Guo, Gastroenterology, 152: 1718-1727, 2017 ) concluded that low-fat diets resulted in a higher metabolic rate and greater fat loss than isocaloric low-carbohydrate diets.

However, low-carb enthusiasts persisted. They argued that the studies included in the meta-analysis were too short to adequately measure the metabolic effects of a low-carb diet. Recently, a study has been published in the British Medical Journal (CB Ebbeling et al, BMJ 2018, 363:k4583 ) that appears to vindicate their position.

Are low carb diets best for long term weight loss?

Low-carb enthusiasts claim the study conclusively shows that low-carb diets are best for losing weight and for keeping it off once you have lost it. They are saying that it is time to shift away from counting calories and from promoting low-fat diets and focus on low-carb diets instead if we wish to solve the obesity epidemic. In this article I will focus on three issues:

  • How good was the study?
  • What were its limitations?
  • Are the claims justified?

 

How Was The Study Designed?

low carb diet studyThe investigators started with 234 overweight adults (30% male, 78% white, average age 40, BMI 32) recruited from the campus of Framingham State University in Massachusetts. All participants were put on a diet that restricted calories to 60% of estimated needs for 10 weeks. The diet consisted of 45% of calories from carbohydrate, 30% from fat, and 25% from protein. [So much for the claim that the study showed low-carb diets were more effective for weight loss. The diet used for the weight loss portion of the diet was not low-carb.]

During the initial phase of the study 161 of the participants achieved 10% weight loss. These participants were randomly divided into 3 groups for the weight maintenance phase of the study.

  • The diet composition of the high-carb group was 60% carbohydrate, 20% fat, and 20% protein.
  • The diet composition of the moderate-carb group was 40% carbohydrate, 40% fat, and 20% protein.
  • The diet composition of the low-carb group was 20% carbohydrate, 60% fat, and 20% protein.

Other important characteristics of the study were:

  • The weight maintenance portion of the study lasted 5 months – much longer than any previous study.
  • All meals were designed by dietitians and prepared by a commercial food service. The meals were either served in a cafeteria or packaged to be taken home by the participants.
  • The caloric content of the meals was individually adjusted on a weekly basis so that weight was kept within a ± 4-pound range during the 5-month maintenance phase.
  • Sugar, saturated fat, and sodium were limited and kept relatively constant among the 3 diets.

120 participants made it through the 5-month maintenance phase.

 

Do Low-Carb Diets Help Maintain Weight Loss?

low carb diet maintain weight lossThe results were striking:

  • The low-carb group burned an additional 278 calories/day compared to the high-carb group and 131 calories/day more than the moderate-carbohydrate group.
  • These differences were even higher for those individuals with higher insulin secretion at the beginning of the maintenance phase of the study.
  • These differences lead the authors to hypothesize that low-carb diets might be more effective for weight maintenance than other diets.

 

What Are The Pros And Cons Of This Study?

low carb diet pros and consThis was a very well-done study. In fact, it is the most ambitious and well-controlled study of its kind. However, like any other clinical study, it has its limitations. It also needs to be repeated.

The pros of the study are obvious. It was a long study and the dietary intake of the participants was tightly controlled.

As for cons, here are the three limitations of the study listed by the authors:

#1: Potential Measurement Error: This section of the paper was a highly technical consideration of the method used to measure energy expenditure. Suffice it to say that the method they used to measure calories burned per day may overestimate calories burned in the low-carb group. That, of course, would invalidate the major findings of the study. It is unlikely, but it is why the study needs to be repeated using a different measure of energy expenditure.

#2: Compliance: Although the participants were provided with all their meals, there was no way of being sure they ate them. There was also no way of knowing whether they may have eaten other foods in addition to the food they were provided. Again, this is unlikely, but cannot be eliminated from consideration.

#3: Generalizability: This is simply an acknowledgement that the greatest strength of this study is also its greatest weakness. The authors acknowledged that their study was conducted in such a tightly controlled manner it is difficult to translate their findings to the real world. For example:

  • Sugar and saturated fat were restricted and were at very similar levels in all 3 diets. In the real world, people consuming a high-carb diet are likely to consume more sugar than people in the other diet groups. Similarly, people consuming the low-carb diet are likely to consume more saturated fat than people in the other diet groups.
  • Weight was kept constant in the weight maintenance phase by constantly adjusting caloric intake. Unfortunately, this seldom happens in the real world. Most people gain weight once they go off their diet – and this is just as true with low-carb diets as with other diets.
  • The participants had access to dietitian-designed prepared meals 3 times a day for 5 months. This almost never happens in the real world. The authors said “…these results [their data] must be reconciled with the long-term weight loss trials relying on nutrition education and behavioral counseling that find only a small advantage for low carbohydrate compared with low fat diets according to several recent meta-analyses.” [I would add that in the real world, people do not even have access to nutritional education and behavioral modification.]

 

low carb diet and youWhat Does This Study Mean For You?

  • This study shows that under very tightly controlled conditions (dietitian-prepared meals, sugar and saturated fat limited to healthy levels, calories continually adjusted so that weight remains constant) a low-carb diet burns more calories per day than a moderate-carb or high-carb diet. These findings show that it is theoretically possible to increase your metabolic weight and successfully maintain a healthy weight on a low-carb diet. These are the headlines you probably saw. However, a careful reading of the study provides a much more nuanced viewpoint. For example, the fact that the study conditions were so tightly controlled makes it difficult to translate these findings to the real world.
  • In fact, the authors of the study acknowledged that multiple clinical studies show this almost never happens in the real world. These studies show that most people regain the weight they have lost on low-carb diets. More importantly, the rate of weight regain is virtually identical on low-carb and low-fat diets. Consequently, the authors of the current study concluded “…translation [of their results to the real world] requires exploration in future mechanistic oriented research.” Simply put, the authors are saying that more research is needed to provide a mechanistic explanation for this discrepancy before one can make recommendations that are relevant to weight loss and weight maintenance in the real world.
  • The authors also discussed the results of their study in light of a recent, well-designed 12-month study (CD Gardener et al, JAMA, 319: 667-669, 2018 ) that showed no difference in weight change between a healthy low-fat versus a healthy low-carbohydrate diet. That study also reported that the results were unaffected by insulin secretion at baseline. The authors of the current study noted that “…[in the previous study] participants were instructed to minimize or eliminate refined grains and added sugars and maximize intake of vegetables. Probably for this reason, the reported glycemic load [effect of the diet on blood sugar levels] of the low-fat diet was very low…and similar to [the low-carb diet].” In short, the authors of the current study were acknowledging that diets which focus on healthy, plant-based carbohydrates and eliminate sugar, refined grains, and processed foods may be as effective as low-carb diets for helping maintain a healthy weight.
  • This would also be consistent with previous studies showing that primarily plant-based, low-carb diets are more effective at maintaining a healthy weight and better health outcomes long-term than the typical American version of the low-fat diet, which is high in sugar and refined grains. In contrast, meat-based, low-carb diets are no more effective than the American version of the low-fat diet at preventing weight gain and poor health outcomes. I have covered these studies in detail in my book “Slaying The Food Myths.”

Consequently, the lead author of the most recent study has said: “The findings [of this study] do not impugn whole fruits, beans and other unprocessed carbohydrates. Rather, the study suggests that reducing foods with added sugar, flour, and other refined carbohydrates could help people maintain weight loss….” This is something we all can agree on, but strangely this is not reflected in the headlines you may have seen in the media.

The Bottom Line

 

  • A recent study compared the calories burned per day on a low-carb, moderate-carb, and high-carb diet. The study concluded that the low-carb diet burned significantly more calories per day than the other two diets and might be suitable for long-term weight control. If confirmed by subsequent studies, this would be the first real evidence that low-carb diets are superior for maintaining a healthy weight.
  • However, the study has some major limitations. For example, it used a methodology that may overestimate the benefits of a low-carb diet, and it was performed under tightly controlled conditions that can never be duplicated in the real world. As acknowledged by the authors, this study is also contradicted by multiple previous studies. Further studies will be required to confirm the results of this study and show how it can be applied in the real world.
  • In addition, the kind of carbohydrate in the diet is every bit as important as the amount of carbohydrate. The authors acknowledge that the differences seen in their study apply mainly to carbohydrates from sugar, refined grains, and processed foods. They advocate diets with low glycemic load (small effects on blood sugar and insulin levels) and acknowledge this can also be achieved by incorporating low-glycemic load, plant-based carbohydrates into your diet. This is something we all can agree on, but strangely this is not reflected in the headlines you may have seen in the media.
  • Finally, clinical studies report averages, but none of us are average. When you examine the data from the current study, it is evident that some participants burned more calories per hour on the high-carb diet than other participants did on the low carb diet. That reinforces the observation that some people lose weight more effectively on low-carb diets while others lose weight more effectively on low-fat diets. If you are someone who does better on a low-carb diet, the best available evidence suggests you will have better long-term health outcomes on a primarily plant-based, low-carb diet such as the low-carb version of the Mediterranean diet.

For more details read the article above.

 

 

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

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