Does Resveratrol Improve Blood Sugar Control?

Written by Dr. Steve Chaney on . Posted in Food and Health, Issues, Supplements and Health

Is The Promise of Resveratrol True?

Author: Dr. Stephen Chaney

blood sugar testIt was just a few years ago that resveratrol was the latest “miracle nutrient”. It was featured on Dr. Oz and on 60 Minutes. It was hot! Today you see dueling headlines. The headlines one week proclaim the benefits of resveratrol. Next week’s headlines say that it’s all hype. What’s a person to believe?

Let me take you behind the headlines to look at the actual studies and answer some important questions.

1)    What do we actually know about the benefits of resveratrol?

2)    Is the evidence for beneficial effects of resveratrol where it should be considering the number of clinical studies that have been published?

3)    What additional studies need to be done before we can be sure that resveratrol is beneficial?

4)    Should you wait until we are absolutely certain resveratrol is beneficial, before you start using it? This is perhaps the most important question of all.

To answer those questions, let’s examine the study behind one of the latest headlines, namely: “Resveratrol Improves Blood Sugar Control in Diabetics”. One of the promises of resveratrol has been that it might help diabetics and pre-diabetics who struggle with blood sugar control. However, this promise was based on animal studies. The study that generated the headlines in question was a meta-analysis of recently published human clinical trials in this area (Liu et al, Am. J. Clin. Nut., 2014, doi: 10.3945/ajcn.113.082024).

Does Resveratrol Improve Blood Sugar Control?

The meta-analysis included 11 published placebo controlled double blind clinical studies looking at the effects of resveratrol supplementation on fasting blood sugar levels, insulin levels, hemoglobin A1c (a measure of blood sugar control) and insulin resistance (a measure closely associated with type 2 diabetes).

A strength of this meta-analysis is the fact that it included 11 clinical studies. However, a weakness of this analysis is that these studies utilized a wide variety of resveratrol doses (10 mg/day to 1 gram/day), a wide variety of end points and both diabetic and non-diabetic patients. That means that there were only a few studies with common population groups, resveratrol doses, and end points.

The conclusions of the study (and the headlines you may have seen) were that:

•    Resveratrol appeared to improve blood sugar control (based on improvements in fasting blood sugar levels, insulin levels, hemoglobin A1c and insulin resistance) in diabetics.

•    No consistent effect of resveratrol on blood sugar control was seen in non-diabetics.

How Good Are These Studies?

While these studies are very promising, they are bot definitive.  There were only 3 published clinical studies in diabetics. While all 3 of the studies showed a positive effect of resveratrol supplementation:

•    The doses used were different in each study (ranging from 10 mg/day to 1 gram/day)

•    Each study measured different end points (one measured blood glucose, insulin levels, hemoglobin A1c and insulin resistance, one measured blood glucose and hemoglobin A1c and the third measured insulin resistance).

As a research scientist I would like to see more studies done at comparable doses and measuring the same end points – we scientists always want more studies.

Similarly, there was not enough consistency in the studies with non-diabetics to draw a firm conclusion. (3 were with obese patients, 3 were with patients with cardiovascular disease, 1 was with patients with metabolic syndrome and 1 was with perfectly healthy subjects.)

If you really wanted to see if something like resveratrol helps non-diabetics with blood sugar control, you would want to start with people who are already experiencing some difficulties with blood sugar control (pre-diabetics or patients with metabolic syndrome) and follow them for a couple of years to see if resveratrol reduces the number of them who become diabetic.

Are The Headlines Just Hype?

Newspaper HeadlinesDoes that mean that the blood sugar benefits of resveratrol are just hype? The answer is no. There is a difference between “very promising, but not yet definitive” and “hype”. We shouldn’t be surprised that human studies on the health benefits of resveratrol are not yet definitive. Science moves slowly. It often takes decades of scientific research before promising concepts are widely accepted by the scientific community.

When a research area is as young as this one, we sometimes need to go beyond the clinical studies and look at the totality of evidence. In this case:

•    In mice resveratrol exerts its beneficial effects by turning on a specific anti-aging gene called SIRT1 (Cell Metabolism, 15: 675-690, 2012). In humans, resveratrol appears to activate the same genetic pathways as in mice (Journal of Clinical Endocrinology & Metabolism, 96: 1409-1414, 2011).

•    In obese mice resveratrol improves markers of blood sugar control (Nature, 444: 337-342, 2006). Published clinical studies in diabetic humans also show improvements in blood sugar control (Journal of Clinical Nutrition, 2014, doi: 10.3945/ajcn.113.082024).

So while more and better clinical studies are needed to be absolutely certain that resveratrol helps improve blood sugar control, the evidence supporting that effect is substantial.

What Should You Do?

The ONLY important question for each of you is probably: “Should I wait a decade or two until we are absolutely sure about the health benefits of resveratrol before I take a resveratrol supplement?” That question is ultimately yours to answer. It’s all about benefits and risk.

Benefits – In animal studies resveratrol clearly improves blood sugar control. The human clinical studies published to date are consistent with the animal studies.

Risk – Current data suggest that resveratrol appears to be safe, even at high doses. For example, one recent study indicated that up to 5 gm/day is safe (Cancer Epidemiology BioMarkers & Prevention, volume 16:1246-1262, 2007), but I wouldn’t personally recommend exceeding 100-200 mg/day.

The Bottom Line:

1)     Don’t get too excited about the headlines suggesting that resveratrol might help improve blood sugar control in diabetics. The few human clinical studies that have been published to date are consistent with previous animal studies. That is very promising, but more studies are needed before we can be absolutely confident that resveratrol supplementation is beneficial for diabetics.

2)     Similarly, don’t be discouraged by the headlines suggesting that resveratrol does not help with blood sugar control in non-diabetics. Those results are preliminary as well.

3)     That doesn’t mean that the headlines are just hype. It takes decades to accumulate definitive proof that any kind of food or nutrient offers proven benefits, and the bulk of human clinical research on reveratrol has occurred in the last couple of years. We are exactly where we should expect to be at this point in time.

4)     With something as promising as resveratrol, the real question becomes whether you can afford to wait a decade or two until you know whether the potential benefits have been definitely proven. That question is up to you. On the plus side, current data suggest that resveratrol is highly promising for blood sugar control. In addition, resveratrol appears to be safe, even at high doses, but I wouldn’t personally recommend exceeding 100-200 mg/day.

5)     We already know that weight control, exercise and a healthy diet improve blood sugar control. You should think of resveratrol as something you may wish to add to a healthy lifestyle, not as a substitute for a healthy lifestyle.

6)     If you are diabetic and decide to try a resveratrol supplement, be sure to work with your physician so they can modify your dose of insulin or blood sugar medication as necessary.

7)     Finally, you may be asking whether resveratrol supplements are even necessary. Can’t you just get all the resveratrol you need from a glass or two of red wine? Stay tuned. I’ll have the answer to that question in a couple of weeks.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

Tags: , , , ,

Trackback from your site.

Leave a comment

Recent Videos From Dr. Steve Chaney

READ THE ARTICLE
READ THE ARTICLE

Latest Article

Shermer’s Neck Pain Relief

Posted January 16, 2018 by Dr. Steve Chaney

Shermer’s Neck Is An Ultra-Cyclist’s Nightmare

Author: Julie Donnelly, LMT – The Pain Relief Expert

Editor: Dr. Steve Chaney

shermer's neck pain ultracyclistShermer’s Neck is a condition where the muscles of the back of your neck become so tight that they lose the ability to hold your head up. It is a condition most frequently associated with ultracycling.

Do you love to cycle?  Perhaps you’re an ultracyclist and ride for many hours every week.  If you are, you may already know about Shermer’s Neck.

As you are well-aware, an ultracyclist leans forwardThis is called the “aerodynamic position.” When you do that, you are slicing through the wind, and you aren’t losing speed when the wind hits your chest. However, you need to hold your head up to see where you are going and maintain that position for several hours. That is what causes Shermer’s Neck.

Shermer’s Neck And The Non-Athlete

shermer's neck pain painterYou don’t have to be an ultracyclist to suffer from Shermer’s Neck. Do you do anything that has you look up for hours, such as being a house painter? Even something as simple as having your computer screen too high can force you to have your head tilted up for long periods of time while working.

If so, Shermer’s Neck can still affect you, and seriously impact your life. Fortunately, non-athletes don’t usually have as severe a problem as the ultracyclists.

Why Does Looking Up Cause Shermer’s Neck?

shermer's neck painYour posterior neck muscles primarily originate at the middle of your back, along your spine. They go up your back and neck, and insert into either your cervical spine, or the bottom of your skull. When these muscles contract, they pull your head back.  When the muscles of the posterior neck contract, if you are standing, you’ll be looking at the ceiling. If you’re a cyclist, your posterior neck muscles contract in order for you to look forward.

How To Treat The Muscles That Cause Shermer’s Neck

shermer's neck pain pinchThe primary muscles that cause Shermer’s Neck are:

To treat the muscles that cause a repetitive strain injury in your neck, tilt your head back and pinch the muscle that is right next to your spine.

shermer's neck pain reliefNext, press the three middle fingers of your opposite hand deeply into the muscle fibers, going from the base of your scalp to as far as you can reach down the center of your back, right alongside your spinal column.

While pressing deeply, slowly lower your chin toward your chest so you are stretching the muscle fibers.  Don’t let your hand slide on your neck or you will miss the stretch.

Do both self-treatments on both sides of your neck.

shermer's neck pain relief bookYou can find the full treatments for your entire neck and upper back by going to my book, Treat Yourself to Pain-Free Living . This book has treatments for your entire body, from your head to your feet.  YOU are your own Best Therapist!  Stop pain quickly and easily with self-treatments you can do anytime, anyplace.  Get relief from Shermer’s Neck pain by following the steps above.

Wishing you well,

Julie Donnelly

 

About The Author

julie donnellyJulie Donnelly is a Deep Muscle Massage Therapist with 20 years of experience specializing in the treatment of chronic joint pain and sports injuries. She has worked extensively with elite athletes and patients who have been unsuccessful at finding relief through the more conventional therapies.

She has been widely published, both on – and off – line, in magazines, newsletters, and newspapers around the country. She is also often chosen to speak at national conventions, medical schools, and health facilities nationwide.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

UA-43257393-1