Does Resveratrol Improve Blood Sugar Control?

Written by Dr. Steve Chaney on . Posted in Food and Health, Issues, Supplements and Health

Is The Promise of Resveratrol True?

Author: Dr. Stephen Chaney

blood sugar testIt was just a few years ago that resveratrol was the latest “miracle nutrient”. It was featured on Dr. Oz and on 60 Minutes. It was hot! Today you see dueling headlines. The headlines one week proclaim the benefits of resveratrol. Next week’s headlines say that it’s all hype. What’s a person to believe?

Let me take you behind the headlines to look at the actual studies and answer some important questions.

1)    What do we actually know about the benefits of resveratrol?

2)    Is the evidence for beneficial effects of resveratrol where it should be considering the number of clinical studies that have been published?

3)    What additional studies need to be done before we can be sure that resveratrol is beneficial?

4)    Should you wait until we are absolutely certain resveratrol is beneficial, before you start using it? This is perhaps the most important question of all.

To answer those questions, let’s examine the study behind one of the latest headlines, namely: “Resveratrol Improves Blood Sugar Control in Diabetics”. One of the promises of resveratrol has been that it might help diabetics and pre-diabetics who struggle with blood sugar control. However, this promise was based on animal studies. The study that generated the headlines in question was a meta-analysis of recently published human clinical trials in this area (Liu et al, Am. J. Clin. Nut., 2014, doi: 10.3945/ajcn.113.082024).

Does Resveratrol Improve Blood Sugar Control?

The meta-analysis included 11 published placebo controlled double blind clinical studies looking at the effects of resveratrol supplementation on fasting blood sugar levels, insulin levels, hemoglobin A1c (a measure of blood sugar control) and insulin resistance (a measure closely associated with type 2 diabetes).

A strength of this meta-analysis is the fact that it included 11 clinical studies. However, a weakness of this analysis is that these studies utilized a wide variety of resveratrol doses (10 mg/day to 1 gram/day), a wide variety of end points and both diabetic and non-diabetic patients. That means that there were only a few studies with common population groups, resveratrol doses, and end points.

The conclusions of the study (and the headlines you may have seen) were that:

•    Resveratrol appeared to improve blood sugar control (based on improvements in fasting blood sugar levels, insulin levels, hemoglobin A1c and insulin resistance) in diabetics.

•    No consistent effect of resveratrol on blood sugar control was seen in non-diabetics.

How Good Are These Studies?

While these studies are very promising, they are bot definitive.  There were only 3 published clinical studies in diabetics. While all 3 of the studies showed a positive effect of resveratrol supplementation:

•    The doses used were different in each study (ranging from 10 mg/day to 1 gram/day)

•    Each study measured different end points (one measured blood glucose, insulin levels, hemoglobin A1c and insulin resistance, one measured blood glucose and hemoglobin A1c and the third measured insulin resistance).

As a research scientist I would like to see more studies done at comparable doses and measuring the same end points – we scientists always want more studies.

Similarly, there was not enough consistency in the studies with non-diabetics to draw a firm conclusion. (3 were with obese patients, 3 were with patients with cardiovascular disease, 1 was with patients with metabolic syndrome and 1 was with perfectly healthy subjects.)

If you really wanted to see if something like resveratrol helps non-diabetics with blood sugar control, you would want to start with people who are already experiencing some difficulties with blood sugar control (pre-diabetics or patients with metabolic syndrome) and follow them for a couple of years to see if resveratrol reduces the number of them who become diabetic.

Are The Headlines Just Hype?

Newspaper HeadlinesDoes that mean that the blood sugar benefits of resveratrol are just hype? The answer is no. There is a difference between “very promising, but not yet definitive” and “hype”. We shouldn’t be surprised that human studies on the health benefits of resveratrol are not yet definitive. Science moves slowly. It often takes decades of scientific research before promising concepts are widely accepted by the scientific community.

When a research area is as young as this one, we sometimes need to go beyond the clinical studies and look at the totality of evidence. In this case:

•    In mice resveratrol exerts its beneficial effects by turning on a specific anti-aging gene called SIRT1 (Cell Metabolism, 15: 675-690, 2012). In humans, resveratrol appears to activate the same genetic pathways as in mice (Journal of Clinical Endocrinology & Metabolism, 96: 1409-1414, 2011).

•    In obese mice resveratrol improves markers of blood sugar control (Nature, 444: 337-342, 2006). Published clinical studies in diabetic humans also show improvements in blood sugar control (Journal of Clinical Nutrition, 2014, doi: 10.3945/ajcn.113.082024).

So while more and better clinical studies are needed to be absolutely certain that resveratrol helps improve blood sugar control, the evidence supporting that effect is substantial.

What Should You Do?

The ONLY important question for each of you is probably: “Should I wait a decade or two until we are absolutely sure about the health benefits of resveratrol before I take a resveratrol supplement?” That question is ultimately yours to answer. It’s all about benefits and risk.

Benefits – In animal studies resveratrol clearly improves blood sugar control. The human clinical studies published to date are consistent with the animal studies.

Risk – Current data suggest that resveratrol appears to be safe, even at high doses. For example, one recent study indicated that up to 5 gm/day is safe (Cancer Epidemiology BioMarkers & Prevention, volume 16:1246-1262, 2007), but I wouldn’t personally recommend exceeding 100-200 mg/day.

The Bottom Line:

1)     Don’t get too excited about the headlines suggesting that resveratrol might help improve blood sugar control in diabetics. The few human clinical studies that have been published to date are consistent with previous animal studies. That is very promising, but more studies are needed before we can be absolutely confident that resveratrol supplementation is beneficial for diabetics.

2)     Similarly, don’t be discouraged by the headlines suggesting that resveratrol does not help with blood sugar control in non-diabetics. Those results are preliminary as well.

3)     That doesn’t mean that the headlines are just hype. It takes decades to accumulate definitive proof that any kind of food or nutrient offers proven benefits, and the bulk of human clinical research on reveratrol has occurred in the last couple of years. We are exactly where we should expect to be at this point in time.

4)     With something as promising as resveratrol, the real question becomes whether you can afford to wait a decade or two until you know whether the potential benefits have been definitely proven. That question is up to you. On the plus side, current data suggest that resveratrol is highly promising for blood sugar control. In addition, resveratrol appears to be safe, even at high doses, but I wouldn’t personally recommend exceeding 100-200 mg/day.

5)     We already know that weight control, exercise and a healthy diet improve blood sugar control. You should think of resveratrol as something you may wish to add to a healthy lifestyle, not as a substitute for a healthy lifestyle.

6)     If you are diabetic and decide to try a resveratrol supplement, be sure to work with your physician so they can modify your dose of insulin or blood sugar medication as necessary.

7)     Finally, you may be asking whether resveratrol supplements are even necessary. Can’t you just get all the resveratrol you need from a glass or two of red wine? Stay tuned. I’ll have the answer to that question in a couple of weeks.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

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Latest Article

Eye Pain Relief

Posted August 20, 2019 by Dr. Steve Chaney

A Simple Treatment To Make Your Eye Pain Disappear

Author: Julie Donnelly, LMT –The Pain Relief Expert

Editor: Dr. Steve Chaney

 

good newsAs the song goes: ”…Summertime and the living is e-a-s-y….”  Here in Florida we know that the living is easy because it’s so hot who wants to be doing anything except either sitting in the shade, or inside in the air conditioning.  Personally, I don’t think this summer was so bad, especially the evenings, but then, I really hate the cold so maybe my opinion is biased.

To stay in alignment with “living is easy,” I’m taking the advice of a few experts who teach easy ways to stay calm, motivated, and happy.  I’m taking a 30-day break from the news.  It’s so much in my face lately that it’s really affecting me in a very negative way.  So far, I’m two days into my 30 days.

I’ve decided that I want to take away some of the stress that seems to be normal for everyone. To that end I was listening to a speaker who was talking about the dangers of stress and what it does to the body.  Really frightening! He was saying that negative news sells and, for example, in the 1990’s in one city of the USA, homicides had gone down 42%, but the local TV station increased its coverage of homicides by 700%.  It’s only gotten worse in 2019.  It’s making us think we live in a dangerous country, and it sure isn’t helping our blood pressure.

To solve that problem, this speaker recommended going on a “news fast” for 30 days. Absolutely no negative news of any kind for a full month.  I’m surrounded by news all day so it’s a challenge, but I’ve found a great substitute:  www.GoodNewsNetwork.org.  Their mission is to be an antidote to the barrage of negativity experienced in the mainstream media.

So, I want to share this with you, and if you have any other good news stations/websites you love, please feel free to share it with me.

I think I’m off to the beach with a big umbrella and a thermos of ice-cold tea!  Living the e-a-s-y life!

Have a relaxing month!

 

Eye Strain And Eye Pain

 

eye pain reliefThis week I had a client come to the office with a situation that is pretty rare.  He described his pain as on his eyeball, which then referred to the entire top half of his skull.  It was like drawing a line that went under his eyes, through his ears, and around his head.  It was definitely a headache but concentrated on his eyes.  He was in desperate need of eye pain relief.

This client works in an industry that has the computer screen changing frequently and he’s needing to locate information on the new screen quickly.  He has experienced eye strain before, but other times just having the weekend off has resolved the problem.  This time the pain didn’t go away.

We don’t ever think about the muscles that move our eyes, but they can get repetitively strained just like any other muscle in the body.  This especially happens if you are watching something that has your eye moving back and forth rapidly, like a game on your computer or phone.

The muscles that are most prone to a repetitive strain injury are the ones on the top of the eye and on the outside of the eye.  I’m not an eye doctor so I can’t explain why these two muscles cause more problems than the others, but my experience has shown this to be the truth.

 

Eye Pain Relief

 

eye pain relief massageThe treatment is simple, but you need to do it cautiously.  If you wear contacts, you’ll need to remove them. The pressure is VERY light.

Put your fingertip directly onto your eyeball and press down GENTLY.

Slide your finger from the top of your eyeball to the outside of your eyeball.

If you find a point where it is tender, that’s the spasm that is putting a strain on your eyeball.  Just leave your fingertip on that point for 30 seconds.

You may even get a light show while doing this, with different shapes and colors.

You’ll find that this simple treatment will soothe tired eyes at the end of the day.  But remember, the pressure needs to be light and gentle.

Why stay in pain when it’s so easy to find the muscular source of the problem and eliminate it?

 

 

Treat Yourself to Pain-Free Living (https://julstromethod.com/product/treat-yourself-to-pain-free-living-hardcopy/) is filled with over 100 pictures pain free living bookand descriptions proven to show you how to find and self-treat muscle spasms from head to foot!

Join the 1000’s of people worldwide who have discovered that tight muscles were the true source of pains they thought were from arthritis, fibromyalgia, and other serious conditions.  You have nothing to lose, and everything to gain by releasing tight muscles.

 

Treat Yourself to Pain-Free Living is your step-by-step guide to pain relief!

 

 

Wishing you well,

 

Julie Donnelly

 

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

 

About The Author

julie donnellyJulie Donnelly is a Deep Muscle Massage Therapist with 20 years of experience specializing in the treatment of chronic joint pain and sports injuries. She has worked extensively with elite athletes and patients who have been unsuccessful at finding relief through the more conventional therapies.

She has been widely published, both on – and off – line, in magazines, newsletters, and newspapers around the country. She is also often chosen to speak at national conventions, medical schools, and health facilities nationwide.

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