Posts Tagged ‘food alergies’

Should GMO Labeling Be Required For All Food Ingredients?

Written by Dr. Steve Chaney on . Posted in Environment and Health, Food and Health, Issues

When Is GMO Not GMO?

Author: Dr. Stephen Chaney

GMO-freeI’m probably going to get lots of hate mail for this week’s “Health Tips from the Professor” because I’m finally going to tackle the GMO controversy.

You see, the GMO controversy is very much like Washington politics. On one side of the aisle, you have the people who are absolutely convinced that anything GMO is terrible. On the other side of the aisle, you have people who are absolutely convinced that there are no problems with GMO foods. And both sides are convinced that their opponents have absolutely nothing of intelligence to say on the topic.

So almost anything I say about GMO is bound to offend somebody. But nobody ever accused me of being timid, so let’s get started.

What Are The Health Risks Of Genetically Modified Foods?

I’m going to start with the supposed health risks of GMO foods because that’s my area of greatest expertise, and I’m going to evaluate those health risks from the viewpoint of a card-carrying biochemist. I’ve seen the scary pictures and alarming statements posted on many anti-GMO web sites, but objective evidence that genetically modified foods are harmful to humans is underwhelming at present.

Modifications to DNA And Health Risks

Let’s start at the beginning. Genetic modification occurs in the DNA, and on that basis GMO foods have some potential, but yet unproven, risks. Let me give you an example:

  • Some genetically modified foods carry genes for naturally occurring pesticides so that if bugs try to eat the leaves of those plants they will die.
  • When we eat foods occasionally small pieces of their DNA will find their way into our intestinal track.
  • We have bacteria in our intestinal tracts that excel at picking up small pieces of DNA and inserting them into their genome.
  • So it is theoretically possible that those bacteria might start producing in our intestines the same pesticides produced by the genetically modified foods we ate.

It is an interesting idea, but to my knowledge one that has not yet been shown to have actually occurred in a human being.

Modifications to Proteins And Health Risks

A more likely risk comes from the proteins contained in genetically modified foods:

  • Genetic modifications in the DNA result in the production of modified proteins, so GMO foods, GMO protein powders and foods made from GMO protein sources can be a source of unsuspected food allergies.
  • Unfortunately, food allergies, especially those from genetically modified protein sources, are very difficult to quantify, so we have no good data on how big a problem this actually is.

However, it would be very surprising if there weren’t some individuals with food allergies to genetically modified proteins.

When Is GMO Not GMO?

Many of the GMO opponents take it one step further and want to label as GMO any food or supplement that contains any ingredient made from a genetically modified food. This is where the science is clearly on the other side of the aisle. With respect to purified sugars, purified oils, vitamins and other purified nutrients obtained from foods there is no difference between GMO and non-GMO because these purified nutrients contain neither DNA nor protein.

 Should GMO Labeling Be Required For All Food Ingredients?

For the most part, it isn’t even possible for most manufacturers to produce foods or supplements with all non-GMO ingredients. When the whole GMO issue first entered public awareness the food industry was guided by the science. It made good business sense for them to create a capacity, a pipeline if you will, to make sure that non-GMO protein sources were available to meet the market demand for companies that wanted to make non-GMO protein products for this new GMO-adverse market.

But, nobody anticipated the emotional demand for non-GMO sugars, oils and the like. There was no scientific basis for that demand, so none of the suppliers created the capacity to meet that demand. Currently there is only enough of those kinds of non-GMO ingredients to meet the needs of the bit players in the market. There simply aren’t enough of those ingredients to satisfy the requirements of any manufacturer who deals in the mass market. That, for example, is the reason big players in the market lobbied against the recent California and Washington State propositions that would have required a food product to be labeled GMO if any ingredient in the food was GMO.

Genetically Modified Foods And The Environment

Now that I have managed to alienate almost everyone, I should point out that there are some non-health issues around GMO foods.

  • The biggest issue is that many of the genetically modified foods contain modifications that make them resistant to herbicides, and that encourages overuse of those herbicides with the resultant pollution of air, soil, and water.
  • Another concern is that the increasing reliance on genetically modified food crops is leading to a decrease in the genetic diversity of those crops, which could make them more susceptible to a new virus or pest in the future. This is a theoretical concern, but there is historical precedence for believing that it could happen.
  • Finally, laws that prevent subsistent farmers from saving their own seed for next season’s planting is a major concern in Third World countries. But, that is more an issue of corporate greed than it is of genetic modification.

The Bottom Line:

What is the take-home lesson for you?

From a health perspective:

  • Genetically modified proteins are likely to be a food allergy risk for some people, but we have no good data on how many people are affected by this kind of food allergy
  • Genetically modified DNA is a theoretical concern because of the ability of intestinal bacteria to pick up pieces of DNA, but we have no evidence at present that this has actually ever caused a problem in people.
  • With respect to sugars, oils, and other nutrients extracted from foods it makes no difference whether the food was GMO or non-GMO

From an environmental perspective:

  • Genetic modifications leading to herbicide resistance are a significant environmental concern because it encourages overuse of herbicides.
  • Lack of genetic diversity from the overuse of GMO food crops is a theoretical concern, but one with historical precedence.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

Recent Videos From Dr. Steve Chaney

READ THE ARTICLE
READ THE ARTICLE

Latest Article

Do Omega-3s Lower Blood Pressure in Young, Healthy Adults?

Posted August 14, 2018 by Dr. Steve Chaney

What Is The Omega-3 Index And Why Is It Important?

Author: Dr. Stephen Chaney

 

Do omega-3s lower blood pressure in healthy adults?

omega-3s lower blood pressure young adultsThe literature on the potential health benefits of omega-3s is very confusing. That’s because a lot of bad studies have been published. Many of them never determined the omega-3 status of their subjects prior to omega-3 supplementation. Others relied on dietary recalls of fish consumption, which can be inaccurate.

Fortunately, a much more accurate measure of omega-3 status has been developed and validated in recent years. It’s called the Omega-3 Index. Simply put, the Omega-3 Index is the percentage of EPA and DHA compared to 26 other fatty acids found in cellular membranes. Using modern technology, it can be determined from a single finger prick blood sample. It is a very accurate reflection of omega-3 intake relative to other fats in the diet over the past few months. More importantly, it is a measure of the omega-3 content of your cell membranes, which is a direct measure of your omega-3 nutritional status.

A recent extension of the Framingham Heart Study reported that participants with an Omega-3 Index >6.8% had a 39% lower risk of cardiovascular disease than those with an Omega-3 Index <4.2% (WS Harris et al, Journal of Clinical Lipidology, 12: 718-724, 2018 ). Although more work needs to be done, an Omega-3 Index of 4% or less is generally considered indicative of high cardiovascular risk, while 8% or better is considered indicative of low cardiovascular risk. For reference, the average American has an Omega-3 Index in the 4-5% range. In Japan, where fish consumption is much higher and cardiovascular risk much lower, the Omega-3 Index is in the 9-11% range.

Previous studies have suggested that omega-3 fatty acids lower blood pressure to a modest extent. Thus, it is not surprising that more recent studies have shown an inverse correlation between Omega-3 Index and blood pressure. However, those studies have been done with older populations, many of whom had already developed high blood pressure.

From a public health point of view, it is much more interesting to investigate whether it might be possible to prevent high blood pressure in older adults by optimizing omega-3 intake in a young, healthy population, most of whom had not yet developed high blood pressure. Unfortunately, there were no studies looking at that population. The current study was designed to fill that gap.

 

How Was The Study Done?

omega-3s lower blood pressure young healthy adultsThe current study (M.G. Filipovic et al, Journal of Hypertension, 36: 1548-1554, 2018 ) was based on data collected from 2036 healthy adults, aged 25-41, from Liechtenstein. They were participants in the GAPP (Genetic and Phenotypic Determinants of Blood Pressure) study. Participants were excluded from the study if they had been diagnosed with high blood pressure and were taking medication to lower their blood pressure. They were also excluded if they had heart disease, chronic kidney disease, other severe illnesses, obesity, sleep apnea, or daily use of non-steroidal anti-inflammatory medications.

Blood samples were collected at the time of their enrollment in the study and frozen for subsequent determination of Omega-3 Index. Blood pressure was also measured at their time of enrollment in two different ways. The first was a standard blood pressure measurement in a doctor’s office.

For the second measurement they were given a wearable blood pressure monitor that recorded their blood pressure over 24 hours every 15 minutes during the day and every 30 minutes while they were sleeping. This is considered more accurate than a resting blood pressure measurement in a doctor’s office because it records the variation in blood pressure, while you are sleeping, while you are exercising, and while you go about your everyday activities.

 

Do Omega-3s Lower Blood Pressure In Young, Healthy Adults?

omega-3s lower blood pressure young adults equipmentNone of the participants in the study had significantly elevated blood pressure. The mean systolic and diastolic office blood pressures were 120±13 and 78±9 respectively. The average Omega-3 Index in this population was 4.6%, which is similar to the average Omega-3 Index in the United States.

When they compared the group with the highest Omega-3 Index (average = 5.8%) with the group with the lowest Omega-3 Index (average = 4.6%):

  • The office measurement of systolic and diastolic blood pressure was decreased by 3.3% and 2.6% respectively
  • While those numbers appear small, the differences were highly significant.
  • The 24-hour blood pressure measurements showed a similar decrease.
  • Blood pressure measurements decreased linearly with increasing Omega-3 Index. [In studies of this kind, a linear dose-response is considered an internal validation of the differences observed between the group with the highest Omega-3 Index and the group with the lowest Omega-3 Index.]

The authors concluded: “A higher Omega-3 Index is associated with statistically significant, clinically relevant, lower systolic and diastolic blood pressure in normotensive, young and healthy individuals. Diets rich omega-3 fatty acids may be a strategy for primary prevention of hypertension.”

 

What Does This Mean For You?

omega-3s lower blood pressure young adults questionPerhaps I should first comment on the significance of the relatively small decrease in blood pressure observed in this study.

  • These were young adults, all of whom had normal or near normal blood pressure.
  • The difference in Omega-3 Index was rather small (5.8% to 4.6%). None of the participants in the study were at the 8% or above that is considered optimal.
  • Liechtenstein is a small country located between Switzerland and Spain. Fish consumption is low and omega-3 supplement consumption is rare.

Under these conditions, even a small, but statistically significant, decrease in blood pressure is remarkable.

We should think of this study as the start of the investigation of the relationship between omega-3 status and blood pressure. Its weakness is that it only shows an association between high Omega-3 Index and low blood pressure. It does not prove cause and effect.

Its strength is that it is consistent with many other studies showing omega-3 fatty acids lower blood pressure. Furthermore, it suggests that the effect of omega-3s on blood pressure may also be seen in young, healthy adults who have not yet developed high blood pressure.

Finally, the authors suggested that a diet rich in omega-3s might reduce the incidence of high blood pressure by slowing the age-related increase in blood pressure that most Americans experience. This idea is logical, but speculative at present.

However, the GAPP study is designed to provide the answer to that question. It is a long-term study with follow-up examinations scheduled every 3-5 years. It will be interesting to see whether the author’s prediction holds true, and a higher Omega-3 Index is associated with a slower increase in blood pressure as the participants age.

 

Why Is The Omega-3 Index Important?

 

The authors of this study said: “The Omega-3 Index is very robust to short-term intake of omega-3 fatty acids and reliably reflects an individual’s long-term omega-3 status and tissue omega-3 content. Therefore, the Omega-3 Index has the potential to become a cardiovascular risk factor as much as the HbA1c is for people with diabetes…” That is a bit of an overstatement. HbA1c is a measure of disease progression for diabetes because it is a direct measure of blood sugar control.

In contrast, Omega-3 Index is merely a risk factor for cardiovascular disease. However, if it is further validated by future studies, it is likely to be as important for predicting cardiovascular risk as are cholesterol levels and markers of inflammation.

However, to me the most important role of Omega-3 Index is in the design of future clinical studies. If anyone really wants to determine whether omega-3 supplementation reduces cardiovascular risk, high blood pressure, diabetes or any other health outcome they should:

  • Start with a population group with an Omega-3 Index in the deficient (4-5%) range.
  • Supplement with omega-3 fatty acids in a double blind, placebo-controlled manner.
  • Show that supplementation brought participants up to an optimal Omega-3 Index of 8% or greater.
  • Look at health outcomes such as heart attacks, cardiovascular deaths, hypertension, stroke, or depression.
  • Continue the study long enough for the beneficial effects of omega-3 supplementation to be measurable. For cardiovascular outcomes the American Heart Association has stated that at least two years are required to obtain meaningful results.

These are the kind of experiments that will be required to give definitive, reproducible results and resolve the confusion about the health effects of omega-3 fatty acids.

 

The Bottom Line

 

An accurate measure of omega-3 status has been developed and validated in recent years. It’s called the Omega-3 Index. Simply put, the Omega-3 Index is the percentage of EPA and DHA compared to 26 other fatty acids found in cellular membranes.

Although more work needs to be done, an Omega-3 Index of 4% or less is generally considered indicative of high cardiovascular risk while 8% or better is considered indicative of low cardiovascular risk.

Previous studies have shown an inverse correlation between Omega-3 Index and blood pressure. However, these studies have been done with older populations, many of whom had already developed high blood pressure.

From a public health point of view, it is much more interesting to investigate whether it might be possible to prevent high blood pressure in older adults by optimizing omega-3 intake in a young, healthy population, most of whom had not yet developed high blood pressure. Until now, there have been no studies looking at that population.

The study described in this article was designed to fill that gap. The participants in this study were ages 25-41, were healthy, and none of them had elevated blood pressure.

When the group with the highest Omega-3 Index (average = 5.8%) was compared with the group with the lowest Omega-3 Index (average = 4.6%):

  • Both systolic and diastolic blood pressure were decreased
  • Blood pressure measurements decreased linearly with increasing Omega-3 Index.

The authors concluded: “A higher Omega-3 Index is associated with statistically significant, clinically relevant, lower systolic and diastolic blood pressure in normotensive, young and healthy individuals. Diets rich omega-3 fatty acids may be a strategy for primary prevention of hypertension.”

Let me translate that last sentence into plain English for you. The authors were saying that optimizing omega-3 intake in young adults may slow the age-related increase in blood pressure and reduce the risk of them developing high blood pressure as they age. This may begin to answer the question “Do omega-3s lower blood pressure in young, healthy adults?”

Or even more simply put: Aging is inevitable. Becoming unhealthy is not.

For more details, read the article above.

 

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

UA-43257393-1