Posts Tagged ‘health’

Are The Benefits Of Resveratrol A Myth?

Written by Dr. Steve Chaney on . Posted in Food and Health, Issues, Supplements and Health

Is Resveratrol Dead?

Author: Dr. Stephen Chaney

Red WineIt seems like just a few years ago that the headlines were proclaiming that resveratrol, a polyphenol found in red wines, grapes and chocolate, was the latest “super nutrient”. It was going to make you younger, smarter and healthier. You probably knew that all of the claims being made at the time could not be true.

But the latest headlines are claiming that resveratrol health benefits are all a myth. Has the resveratrol bubble burst? Was it all just hype?

Before you decide that resveratrol supplements are just a waste of money, let me take you behind the scenes and evaluate the latest study objectively. Let’s talk about what it showed, and didn’t show. But, before we look at the study, let’s review the history of resveratrol.

How Did The Resveratrol Story Get Started?

The resveratrol story started in the 1990’s when Dr. Serge Renaud at Bordeaux University coined the term “French Paradox” to describe the fact that cardiovascular disease incidence was relatively low in the French population despite the fact that they consumed diets high in saturated fat and cholesterol.

People immediately started asking what could possibly explain this discrepancy between the US and French populations? In other words, what could be protecting the French population from their high fat diet? One obviously difference between the French and Americans is that the French consume a lot more red wine – or at least they did before the “French Paradox” publicity turned red wine into a health food. Based on that difference, Dr. Renaud proposed that the French Paradox was due to the high red wine consumption in France.

But, red wine is an alcoholic beverage and overconsumption of alcoholic beverages is a major health problem for many people. And, while alcohol does have some cardiovascular benefits, alcohol consumption was pretty constant across countries.

So the next logical question was what other ingredients in red wine might explain their supposed health benefits. Polyphenols appear to have numerous health benefits, and resveratrol is the major polyphenol in red wine. So resveratrol became the “poster child” for the health benefits of red wine.

Even so, for years resveratrol was a “niche” supplement. It had a loyal following, but it wasn’t a big player in the nutritional supplement market. All that changed in 2009. Dr. David Sinclair at Harvard University had been studying genes that slow the aging process. He had screened thousands of naturally occurring small molecules in hopes of finding some that could turn on those anti-aging genes.

He announced that resveratrol and a few related polyphenols were the most potent activators of those anti-aging genes, and he went on to publish studies showing that resveratrol could help obese mice live longer and lean mice be healthier. All of a sudden resveratrol became a superstar.

But, does resveratrol also work in humans? There are many clinical studies that suggest it does. That’s why I was surprised by the recent headlines proclaiming that the supposed health benefits of resveratrol were myths. So once again, let’s look at the study behind the headlines.

Are The Benefits Of Resveratrol a Myth?

The study behind the headlines (Semba et al, JAMA Internal Medicine, doi: 10.1001/jamainternalmed.2014.1582) followed 783 men and women aged 65 years or older from the Chianti region of Italy for 9 years. None of the participants were taking resveratrol supplements. The investigators estimated resveratrol intake by measuring the concentrations of resveratrol metabolites in the urine.

The investigators measured all cause mortality and the prevalence of heart disease and cancer over the 9 year period and found no correlation between those outcomes and urinary resveratrol metabolites. From those data the authors concluded that “Resveratrol levels achieved with a Western diet did not have a substantial influence on health status or mortality risk of the population in this study.”

The Strengths And Weaknesses of The Study

There are really two important questions – what are the strengths and weaknesses of the study and what does the study actually show?

What are the strengths and weaknesses of the study?

  • A major strength of the study was the measurement of urinary resveratrol metabolites rather than relying on the less accurate dietary recall – although it should be noted that the assays used are relatively new and could benefit from further validation.
  • The main weakness is that it was a relatively small study in a relatively homogeneous population. Most of the resveratrol consumed by this population came from red wine and even the group with the lowest resveratrol intake was drinking 2-3 glasses of red wine per week (You don’t find many teetotalers in the wine growing regions of Italy).

What does the study actually show?

  • The level of resveratrol metabolites in this population directly correlated with alcohol consumption. And, the authors of the study concluded that since the study was done in the Chianti region of Italy, most of the resveratrol came from red wine. So the study actually suggests that red wine consumption has no effect on heart disease, cancer or longevity – in direct contradiction to Renaud’s French Hypothesis.
  • The conclusion that the amount of resveratrol one can obtain from diet alone is unlikely to provide health benefits needs to be replicated in a much larger population group with a wider range of resveratrol intakes from a wider variety of foods before it can be considered definitive.
  • Even if the amount of resveratrol in food does offer no significant health benefits, that information provides little or no guidance when we consider resveratrol supplements, which generally provide much higher levels of resveratrol.

The Bottom Line:

1)    Don’t pay too much attention to the headlines saying that the health benefits of resveratrol are a myth. The study behind the headlines was a small study in a relatively homogeneous population. If anything, it debunked the hypothesis that red wine consumption is responsible for the French Paradox.

2)    The study did suggest that the amount of resveratrol one can obtain from diet alone is unlikely to provide significant health benefits. While that may be true, it is irrelevant when considering resveratrol supplements because they provide much higher amounts of resveratrol.

3)    The clinical studies on resveratrol supplements are very encouraging, but not yet definitive (see, for example, my “Health Tips From the Professor” article on resveratrol and blood sugar control. That’s to be expected at this stage. It generally takes decades of studies before the scientific community reaches consensus on anything. In the meantime you will continue to see alternating headlines proclaiming the miracles and the myths of resveratrol.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

The Two Biggest Misconceptions About Supplementation

Written by Dr. Steve Chaney on . Posted in Issues, Supplements and Health

Secrets You Need To Know

Author: Dr. Stephen Chaney

Nutrition MythsIn last week’s “Health Tips From The Professor” I told you the truth behind the headlines that vitamins are a waste of money. This week I’m going to be talking about the two biggest misconceptions that people have about supplementation. These are two secrets you need to know.

The Two Biggest Misconceptions About Supplementation

I won’t keep you in suspense. The answer is pretty simple. The two biggest misconceptions about supplementation that I hear over and over are:

1)     Supplementation can cure disease

2)     It doesn’t matter what you eat (or what supplements you take)

Of course, those statements don’t tell you much by themselves, so let’s delve into the subject more deeply.

Misconception #1: Supplementation can cure disease.

I don’t know how many times I’ve been asked “I have “disease X”. What supplements should I take? – as if supplements were drugs that can be taken to cure a disease.

We shouldn’t think of supplements as drugs that cure diseases. We should think of them as providing the nutrients that are the building blocks of health – or perhaps the ammunition that the body uses to fight diseases. Diseases, after all, are an abnormal state of being, and our bodies have an amazing capacity to fight those diseases.

When we have infections or cancer our body activates its immune system to fight it. When we have inflammation our body tries to put out the fire. When we have damage to our DNA – our genetic information – our body tries to repair it. The list is almost endless. Our bodies are wondrously designed!

Our immune systems require nutrients like protein, B vitamins, antioxidants, zinc and iron. The omega-3 fatty acids, anti-oxidants and polyphenols like resveratrol are anti-inflammatory. Nutrients like antioxidants and polyphenols support DNA repair.

So proper diet and supplementation are not “magic bullets” that cure diseases. They are simply the building blocks that allow the body to do what it does best.

And because no two of us are alike the nutrients that we need the most to allow our bodies to do their job efficiently may be different for each one of us.

So while there is no magic food or supplement that will cure a specific disease, a healthy diet and a holistic approach to supplementation can often work wonders.

Misconception #2: It doesn’t matter what you eat.

This is the flip side of the coin. I often come across people who have been told by the “experts” that the cause of their disease was not related to diet so they shouldn’t worry about what they eat. They are also usually told that supplementation will not do any good.

Let’s take the most extreme example – genetically caused diseases or serious degenerative diseases like multiple sclerosis or Parkinson’s for which the causes are still not fully understood.

It is generally true that these diseases were not caused by poor diet (MS may be the exception because there is some evidence that it can be caused by inadequate vitamin D during childhood). And I know many people who take the “expert’s” advice to heart and eat whatever they like and consider supplementation a waste of money.

Is that a sound approach? Let’s consider.

Any nutritionist will tell you that an inadequate diet can lead to malaise, low energy, inflammation, weakened immune system and impaired wound healing – just to name a few maladies. Even if you don’t end up with the symptoms of a nutritional deficiency, a poor diet can rob you of energy and vitality.

If you layer the consequences of a poor diet on top of the underlying disease, your chances of being able to cope with the disease and function optimally are greatly diminished.

I have come across many people with very serious diseases who are able to function at a very high level through proper diet and a holistic approach to supplementation.

Diet and supplementation did not cure their disease as they quickly discover if they stop supplementing and go back to the way they used to eat, but in many cases you would consider them to be perfectly healthy as long as they keep doing what they have been doing.

The Bottom Line

1) There is no perfect food or supplement that is capable of curing disease, but if you give your body the nutrients that it needs it often has the ability to heal itself.

2) Proper diet and supplementation can make a difference even if the disease was not caused by poor nutrition.

3) Each of us have unique nutritional needs so a holistic approach to diet and supplementation is best.

I didn’t specifically talk about weight control and exercise, but you should know from my previous “Health Tips From The Professor” that I consider them to be an essential part of any holistic health program.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

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How Long Do the Benefits of Supplements Last?

Posted October 23, 2018 by Dr. Steve Chaney

Can Supplements Set You On A Path Towards A Healthier Life?

Author: Dr. Stephen Chaney

 

benefits of supplements heartA recent study (U Alehagen et al, PLOS One, April 11, 2018, 1-15 ) reported that the heart benefits of supplementation with coenzyme Q10 and selenium persisted for 12 years after supplementation ended. You would have thought a story like that would have made the headlines. Nope. Hardly a mention. Perhaps it did not match the narrative of the media and health professionals that supplements are worthless.

This study broke new ground. Most studies last a year or two and report whether there were any benefits of supplementation. A few studies have been extended a few years beyond the original supplementation period and have reported continued benefits of supplementation. However, in those studies the intervention group was still taking supplements. The intervention period was simply extended.

However, this study was unique in that supplementation was discontinued after 4 years. However, the positive effects of supplementation during that four-year period persisted for another 12 years without additional supplementation.

 

How Was The Study Done?

benefits of supplements monitoring heartIn this study 443 elderly individuals (average age =78) were recruited from a rural village in Sweden. They were given either supplements providing 200 mg/day of coenzyme Q10 and 200 mcg/day of selenium yeast or placebo pills. They were followed for four years. At this point the intervention phase of the trial ended, and the participants were followed for another 12 years without supplementation.

Cardiovascular deaths and all-cause mortality were recorded at 4 years (the end of the original intervention period), 10 years, and 12 years. The Swedish health care system is incredibly efficient. None of the participants were lost to follow-up.

Note on study design: Both coenzyme Q10 and selenium have heart health benefits and they compliment each other. Coenzyme Q10 was included in this study because our bodies lose the ability to make coenzyme Q10 as we age. By the time we reach age 80, we only make around half the coenzyme Q10 we made when we were younger. Selenium was included in the study because most Swedes are selenium deficient.

This study measured selenium levels and confirmed that all participants were selenium deficient at the beginning of the study. Selenium levels increased to near optimal in the supplemented group during the 4-year intervention period. In contrast, the placebo group remained selenium deficient.

 

How Long Do the Benefits of Supplements Last?

benefits of supplementationThe results of the study were truly amazing.

When you compared the group that had received coenzyme Q10 and selenium during the first 4 years of the study with the placebo group:

  • Cardiovascular mortality was 38% less and all-cause mortality was 24% less 12 years later in the supplement group.
  • The decrease in cardiovascular mortality lessened slightly with time (53% lower at 4 years, 46% lower at 10 years, and 38% lower at 12 years.
  • In contrast, the decrease in all-cause mortality remained relatively constant.
  • The effect was greater for women (who have lower coenzyme Q10 levels than men) than it was for men.
  • The decrease in cardiovascular mortality was 57% for women and 22% for men.
  • Cardiovascular mortality was decreased by 40-50% for people at high risk of cardiovascular death because of atherosclerosis, diabetes, high blood pressure, or impaired heart function.

Putting This Study Into Perspective

benefits of supplements wellnessI don’t want to read too much into this study. It has multiple limitations:

  • It is a very small study.
  • It is the first study I am aware of that has followed study participants years after supplementation has ended. More studies like this are clearly needed before any firm conclusions can be drawn.
  • It may be unique to Sweden where selenium deficiency is widespread. Selenium deficiency is much less prevalent in some other countries such as the United States.
  • It is possible that once the study population heard about the results of the initial 4-year study they started self-supplementing with coenzyme Q10 and selenium. However, since the participants did not know whether they were in the supplement or placebo group, that would likely affect both groups equally.

However, it is the implications of the study that fascinate me.

  • The authors of the study speculated that the improvement in endothelial cell function (Endothelial cells line the arteries and play an important role in arterial health) and/or decreased inflammation may have persisted long after supplementation stopped.
  • A more interesting idea is that supplementation (or the effects of supplementation) caused modifications to the DNA that were persistent (something we refer to as epigenetics). Moreover, those DNA modifications may have altered gene expression in a manner that reduced heart disease risk.

Much more work needs to be done before we know whether epigenetic modifications were responsible for the persistent benefit of supplementation in this, or any other, study. However, the ramifications of this idea are substantial. We think of supplementation as something that provides benefit only while we are taking the supplement. What if, under the right conditions, supplementation could send us down an entirely different path to better health? That would be worth major headlines.

 

The Bottom Line

 

A recent study in Sweden looked at the effects of supplementation with coenzyme Q10 and selenium on heart health 12 years after supplementation had ended.

  • The study reported that cardiovascular mortality was 38% less and all-cause mortality was 24% less 12 years later in the group that supplemented during the first 4 years.

The study has multiple limitations and needs to be repeated before drawing any definite conclusions. However, if true, it has interesting implications. What if the benefits of supplementation didn’t stop when you stopped supplementing? What if supplementation sent you down an entirely different path, a path towards better health?

For more details, read the article above.

 

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

 

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